Evidence map›Paper›PMID 42786206›Full record

Reviewnpj biomedical innovations2026

Beyond immunity: macrophage plasticity in vascular regeneration.

Si Tong Huo, Taishi Inoue, Clinton S Robbins, Sara S Nunes

Abstract readReview
In one paragraph

Review in npj biomedical innovations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Si Tong HuoUniversity Health Network Research Institutes, Toronto, ON, Canada.
Taishi InoueUniversity Health Network Research Institutes, Toronto, ON, Canada.
Clinton S RobbinsUniversity Health Network Research Institutes, Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-9848-1495
Sara S NunesUniversity Health Network Research Institutes, Toronto, ON, Canada. sara.vasconcelos@utoronto.ca.

Funding

CIHR 410016624Government of Canada's New Frontiers in Research Fund NFRFT-2022-00447
6 · The paper itself

Abstract

Macrophages drive microvascular development, repair, and remodeling in addition to their roles in immunity. Single-cell transcriptomics reveals macrophage subpopulations whose vascular functions exceed the M1/M2 framework. Here we review four mechanisms of macrophage-driven angiogenesis-paracrine secretion, endothelial contact, matrix remodeling, and mural cell crosstalk-and their temporal ordering across development, injury, and disease. Finally, we examine translational strategies and propose a stage-resolved framework for driving revascularization or suppressing tumor angiogenesis.

Identifiers

PMID42786206
PMCPMC13612396

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.