Evidence map›Paper›PMID 42785975›Full record

ArticleRenal failure2026

Sigma-1 receptor protects against renal ischemia-reperfusion injury by enhancing mitophagy via Rac1 regulation.

Siyuan Gong, Yonghong Xiong, Wenyuan Li, Yan Leng, Xinqi Deng, Bihan Wang, Baichuan Yang, Yuhang Yang, Wei Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Siyuan GongDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China.
Yonghong XiongDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China.
Wenyuan LiDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China.
Yan LengDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China.
Xinqi DengDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China.
Bihan WangDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China.
Baichuan YangDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China.
Yuhang YangDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China.
Wei LiDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal ischemia-reperfusion injury (IRI) is a leading cause of acute kidney injury and is associated with mitochondrial dysfunction, excessive reactive oxygen species (ROS) production, and tubular cell apoptosis. Sigma-1 receptor (Sigma1R), an intracellular chaperone, helps maintain mitochondrial homeostasis and cell survival. Here, Sigma1R expression was significantly downregulated in renal IRI. Fluvoxamine treatment ameliorated renal dysfunction and reduced apoptosis

Indexed as

Acute Kidney InjuryMitophagyrac1 GTP-Binding ProteinReceptors, sigmaReperfusion InjuryAnimalsApoptosisCell LineHumansKidneyMaleMembrane Potential, MitochondrialMiceMitochondriaProtein KinasesPTEN-Induced Putative Kinaseparkin proteinProtein KinasesPTEN-Induced Putative Kinaserac1 GTP-Binding ProteinRAC1 protein, humanReactive Oxygen SpeciesReceptors, sigmaSigma-1 ReceptorUbiquitin-Protein LigasesIschemia-reperfusion injurymitophagyRac1sigma-1 receptor

Identifiers

PMID42785975
PMCPMC13618200

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.