ArticleRenal failure2026
Association of immune-inflammatory markers with chronic kidney disease in older adults with obesity: a large-scale cross-sectional study.
Article in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Obesity is a major independent risk factor for chronic kidney disease (CKD). Population-level evidence linking immune dysregulation to CKD in obese individuals remains limited. In this cross-sectional study, we analyzed data from community-dwelling adults aged 65-85 years in Shanghai, China. The immune-inflammatory markers were compared between obese and non-obese groups. The associations between routinely measured immune-inflammatory markers (neutrophils, lymphocytes, platelet-to-lymphocyte ratio [PLR]) and CKD prevalence were evaluated using multivariable logistic regression, restricted cubic splines (RCSs). Obese individuals had higher neutrophil, monocyte, and lymphocyte counts and lower PLR than the non-obese group. Among participants with obese, elevated neutrophil and lymphocyte counts were independently associated with greater odds of CKD (adjusted odds ratio [aOR] for highest tertile: 1.42, 95% confidence interval [CI] 1.07-1.90; and 1.53, 95% CI 1.16-2.01, respectively), whereas higher PLR was associated with reduced odds (aOR 0.70, 95% CI 0.53-0.92). Adjusted RCS plots revealed nonlinear associations. Elevated neutrophils and monocytes together with lower PLR emerged as key immunoinflammatory markers that might be associated with obesity-associated CKD. These findings highlight the clinical potential of routine immune-inflammatory biomarkers for early and precise risk stratification of obesity-related CKD.
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