ArticleLife science alliance2026
Murine IL-2 outperforms human IL-2 in supporting the survival of naïve mouse CD8 T cells in vitro.
Article in Life science alliance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Much of the immunology community relies on human IL-2 to support murine CD8 T-cell expansion in vitro. Although human and murine IL-2 share high similarity in amino acid sequence and exhibit similar biological activity, the potential cross-species implications of this practice remain largely unexamined, representing a significant yet overlooked variable in many in vitro studies that serve as the foundation of T-cell biology. Here, we compared the effects of human and murine IL-2 on CD8 T cells in vitro to uncover potential differences in T-cell biology. Murine IL-2 more effectively supported the survival of mouse naïve CD8 T cells in vitro and induced a distinct phenotype of IL-2 receptor expression on activated mouse CD8 T cells. In addition, murine IL-2 promoted enhanced antigen-independent expansion of memory-like CD8 T cells from naïve animals. Collectively, these findings should encourage laboratories to reevaluate their human IL-2 dosing strategies or consider transitioning to murine IL-2 for in vitro studies using murine CD8 T cells.
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