Evidence map›Paper›PMID 42785471›Full record

ArticleThe Journal of investigative dermatology2026

Post-trial provisions: Unblinding after a randomized blinded trial of spironolactone or doxycycline to treat acne in women.

John S Barbieri, Susan S Ellenberg, Ann Tierney, James Dattilo, Anabel C Mason, Jennifer B Mason, Maryte Papadopoulos, Suzette Baez, David J Margolis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

John S BarbieriDepartment of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Susan S EllenbergDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Ann TierneyDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
James DattiloDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Anabel C MasonDepartment of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Jennifer B MasonDepartment of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Maryte PapadopoulosDepartment of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Suzette BaezDepartment of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
David J MargolisDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA; Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. Electronic address: margo@pennmedicine.upenn.edu.

Funding

A randomized, double-blind, multi-center comparative effectiveness study of spironolactone versus doxycycline hyclate for the treatment of acne in womenU01AR079752 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI David Joel Margolis · 2021 to 2026
$4.2M
NIAMS NIH HHS U01 AR079752
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AcneClinical trialHuman researchNoninferiority trialPost-trial access

Identifiers

PMID42785471
PMCPMC13693684

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.