Evidence map›Paper›PMID 42785295›Full record

ArticleCell genomics2026

MOSHPIT: Accessible, reproducible metagenome data science on the QIIME 2 framework.

Michal Ziemski, Liz Gehret, Anthony Simard, Santiago Castro Dau, Vinzent Risch, Doriela Grabocka, Christos Matzoros, Colin Wood, Paula Momo Cabrera, Rodrigo Hernández-Velázquez and 8 more

Abstract read
In one paragraph

Article in Cell genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Identify contaminants with decontam on the QIIME 2 Framework.Microbiology resource announcements · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Michal ZiemskiDepartment of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland.
Liz GehretDepartment of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland.
Anthony SimardPathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ 86011, USA.
Santiago Castro DauDepartment of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland.
Vinzent RischDepartment of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland.
Doriela GrabockaDepartment of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland.
Christos MatzorosDepartment of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland.
Colin WoodPathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ 86011, USA.
Paula Momo CabreraDepartment of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland.
Rodrigo Hernández-VelázquezDepartment of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland.
Milo R SchärerDepartment of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland.
Felicia SandbergDepartment of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland.
Chloe HermanPathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ 86011, USA.
Keegan EvansPathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ 86011, USA.
Michael S RobesonUniversity of Arkansas for Medical Sciences, Department of Biomedical Informatics, Little Rock, AR 72205, USA.
Evan BolyenDepartment of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland.
J Gregory CaporasoPathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ 86011, USA; Translational Genomics Research Institute, Flagstaff, AZ 86011, USA.
Nicholas A BokulichDepartment of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland. Electronic address: nicholas.bokulich@hest.ethz.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metagenome sequencing has revolutionized functional microbiome analysis across diverse ecosystems but is fraught with technical hurdles. We introduce MOSHPIT (MOdular SHotgun metagenome Pipelines with Integrated provenance Tracking; https://moshpit.qiime2.org)-software built on the QIIME 2/rachis framework (Q2F) that integrates best-in-class CAMI II- and LEMMI-validated metagenome tools with robust provenance tracking and multiple user interfaces-enabling streamlined, reproducible metagenome analysis for all expertise levels. By building on Q2F, MOSHPIT enhances scalability, interoperability, and reproducibility in complex workflows, democratizing and accelerating discovery at the frontiers of metagenomics.

Indexed as

Data ScienceMetagenomeMetagenomicsSoftwareComputational BiologyHumansMicrobiotaReproducibility of Resultsbioinformaticsfunctional annotationmetagenome assemblymicrobiomesmicrobiotaQIIME 2reproducibilityshotgun metagenomicswhole-metagenome sequencing

Identifiers

PMID42785295
PMCPMC13689502

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.