Evidence map›Paper›PMID 42785070›Full record

ArticlePoultry science2026

Isolation, identification, and pathogenicity of Novel Duck Reovirus strain from ducklings in China.

Zhixian Wang, Jia Tan, Haoran Xi, Yao Hu, Xu Lei, Meifang Tan, Jiazhen Wei, Cui Lin, Fanfan Zhang, Yanbing Zeng and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

14 authors.

Zhixian WangInstitute of Animal Husbandry and Veterinary Medicine, Jiangxi Academy of Agricultural Sciences, Nanchang, 330200, China; Jiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, 330045, China.
Jia TanInstitute of Animal Husbandry and Veterinary Medicine, Jiangxi Academy of Agricultural Sciences, Nanchang, 330200, China; Jiangxi Provincial Key Laboratory of Green and Healthy Breeding of Livestock and Poultry, Nanchang, Jiangxi, 330200, China.
Haoran XiInstitute of Animal Husbandry and Veterinary Medicine, Jiangxi Academy of Agricultural Sciences, Nanchang, 330200, China; Jiangxi Provincial Key Laboratory of Green and Healthy Breeding of Livestock and Poultry, Nanchang, Jiangxi, 330200, China.
Yao HuInstitute of Animal Husbandry and Veterinary Medicine, Jiangxi Academy of Agricultural Sciences, Nanchang, 330200, China; Jiangxi Provincial Key Laboratory of Green and Healthy Breeding of Livestock and Poultry, Nanchang, Jiangxi, 330200, China.
Xu LeiNanchang Miaowang Industrial Co., Ltd., Nanchang, 330200, China.
Meifang TanInstitute of Animal Husbandry and Veterinary Medicine, Jiangxi Academy of Agricultural Sciences, Nanchang, 330200, China; Jiangxi Provincial Key Laboratory of Green and Healthy Breeding of Livestock and Poultry, Nanchang, Jiangxi, 330200, China.
Jiazhen WeiJiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, 330045, China; Department of Animal Science, Jiangxi Biological Vocational College, Nanchang, 330200, China.
Cui LinInstitute of Animal Husbandry and Veterinary Medicine, Jiangxi Academy of Agricultural Sciences, Nanchang, 330200, China; Jiangxi Provincial Key Laboratory of Green and Healthy Breeding of Livestock and Poultry, Nanchang, Jiangxi, 330200, China.
Fanfan ZhangInstitute of Animal Husbandry and Veterinary Medicine, Jiangxi Academy of Agricultural Sciences, Nanchang, 330200, China; Jiangxi Provincial Key Laboratory of Green and Healthy Breeding of Livestock and Poultry, Nanchang, Jiangxi, 330200, China.
Yanbing ZengInstitute of Animal Husbandry and Veterinary Medicine, Jiangxi Academy of Agricultural Sciences, Nanchang, 330200, China; Jiangxi Provincial Key Laboratory of Green and Healthy Breeding of Livestock and Poultry, Nanchang, Jiangxi, 330200, China.
Chengcheng WuInstitute of Animal Husbandry and Veterinary Medicine, Jiangxi Academy of Agricultural Sciences, Nanchang, 330200, China; Jiangxi Provincial Key Laboratory of Green and Healthy Breeding of Livestock and Poultry, Nanchang, Jiangxi, 330200, China.
Na LiInstitute of Animal Husbandry and Veterinary Medicine, Jiangxi Academy of Agricultural Sciences, Nanchang, 330200, China; Jiangxi Provincial Key Laboratory of Green and Healthy Breeding of Livestock and Poultry, Nanchang, Jiangxi, 330200, China.
Jiangnan HuangInstitute of Animal Husbandry and Veterinary Medicine, Jiangxi Academy of Agricultural Sciences, Nanchang, 330200, China; Jiangxi Provincial Key Laboratory of Green and Healthy Breeding of Livestock and Poultry, Nanchang, Jiangxi, 330200, China.
Haiqin LiInstitute of Animal Husbandry and Veterinary Medicine, Jiangxi Academy of Agricultural Sciences, Nanchang, 330200, China; Jiangxi Provincial Key Laboratory of Green and Healthy Breeding of Livestock and Poultry, Nanchang, Jiangxi, 330200, China. Electronic address: Lihaiqin522@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Novel duck reovirus (NDRV) is a prevalent pathogen that seriously threatens China's waterfowl industry. It primarily induces hemorrhage and necrosis in the liver and spleen of ducklings, leading to immunosuppression and even causes high mortality in severe cases. In this study, a total of 150 tissue samples were collected from diseased ducks in Jiangxi Province, China. Among these samples, 40 were confirmed to be NDRV-positive. To further characterize the prevalent NDRV strains, virus isolation and identification were carried out using these positive samples, and four strains (NDRV-JX01, NDRV-JX02, NDRV-JX11, NDRV-JX12) were successfully isolated. Phylogenetic analysis based on the σC gene showed that the four strains clustered with the same evolutionary branch as prevalent NDRV strains in China, with the amino acid identity ranging from 94.1% to 99.1%. Pathogenicity revealed that the NDRV-JX01 strain was pathogenic to one‑day‑old mule ducklings, triggering depression, anorexia, and even death, with a mortality rate of 33.3%. Histopathological analysis revealed that lesions were mainly concentrated in the spleen, liver, and bursa of Fabricius, with lesion severity positively correlated with the clinical symptoms and gross lesions. Tissue tropism analysis further indicated that the NDRV-JX01 strain exhibited a broad tissue infection spectrum in ducklings, with the highest viral loads detected in the spleen, liver, and bursa of Fabricius. Moreover, NDRV-JX01 infection was found to trigger hepatic dysfunction and significantly alter the expression profiles of immune-related genes in ducklings. In summary, these findings expand our knowledge of the genetic diversity and pathogenic characteristics of NDRV, and provide reliable theoretical support for the prevention and control of this pathogen in waterfowl.

Indexed as

Novel duck reovirusPathogenicity studyPhylogenetic analysisVirus isolation and identificationσC gene

Identifiers

PMID42785070
PMCPMC13634508

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