Evidence map›Paper›PMID 42785059›Full record

ArticlePoultry science2026

Chlorogenic acid attenuates LPS-induced hepatic oxidative stress in broilers by regulating cyclooxygenase-2 expression.

Dongying Bai, Xueqing Xiao, Wenrui Zhen, Yi Zhang, Ziyue Zhao, Keyuan Lei, Chengjie Zhang, Fangshen Guo, Cai Zhang, Yushu Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dongying BaiDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China; Henan International Joint Laboratory of Animal Welfare and Health Breeding, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, China.
Xueqing XiaoDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China; Henan International Joint Laboratory of Animal Welfare and Health Breeding, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, China.
Wenrui ZhenDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China; Henan International Joint Laboratory of Animal Welfare and Health Breeding, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, China.
Yi ZhangDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China; Henan International Joint Laboratory of Animal Welfare and Health Breeding, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, China.
Ziyue ZhaoDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China; Innovative Research Team of Livestock Intelligent Breeding and Equipment, Science & Technology Innovation Center for Completed Set Equipment, Longmen Laboratory, Luoyang, 471023, China.
Keyuan LeiDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China; Innovative Research Team of Livestock Intelligent Breeding and Equipment, Science & Technology Innovation Center for Completed Set Equipment, Longmen Laboratory, Luoyang, 471023, China.
Chengjie ZhangDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China; Innovative Research Team of Livestock Intelligent Breeding and Equipment, Science & Technology Innovation Center for Completed Set Equipment, Longmen Laboratory, Luoyang, 471023, China.
Fangshen GuoDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China; Henan International Joint Laboratory of Animal Welfare and Health Breeding, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, China.
Cai ZhangDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China; Henan International Joint Laboratory of Animal Welfare and Health Breeding, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, China.
Yushu ZhangDepartment of Agriculture, Graduate School of Science and Technology, Shinshu University, Matsumoto City, 3994511, Japan.
Bingkun ZhangState Key Laboratory of Animal Nutrition, Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Yanbo MaDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China; Henan International Joint Laboratory of Animal Welfare and Health Breeding, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, China; Innovative Research Team of Livestock Intelligent Breeding and Equipment, Science & Technology Innovation Center for Completed Set Equipment, Longmen Laboratory, Luoyang, 471023, China. Electronic address: mayanbo_haust@haust.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune stress can impair growth performance and induce hepatic oxidative injury; however, the protective potential and underlying mechanisms of the dietary phenolic compound chlorogenic acid (CGA) remain unclear. In this study, we investigated whether CGA alleviates lipopolysaccharide (LPS)-induced hepatic oxidative damage in broilers and explored the involvement of cyclooxygenase-2 (COX-2). Since LPS challenge markedly upregulated PTGS2 (encoding COX-2) and COX-2 is closely associated with redox homeostasis, the selective COX-2 inhibitor celecoxib was included as a pharmacological comparator to determine whether the hepatoprotective effects of CGA are associated with COX-2 regulation. LPS challenge impaired growth performance, as indicated by decreased average daily gain and increased feed conversion ratio, elevated serum corticosterone levels, reduced hepatic antioxidant capacity and antioxidant enzyme activities (CAT and SOD), and increased lipid peroxidation (MDA). Dietary supplementation with CGA (1000 mg/kg) partially reversed these alterations. Transcriptome analysis suggested the involvement of FoxO signaling, and CGA downregulated PTGS2 and NOX1 while upregulating Nrf2, HO-1, FoxO1/3, GPX1, and GST expression. Celecoxib partially reproduced the effects of CGA by reducing PTGS2 and NOX1 expression and increasing FoxO3 expression. Collectively, CGA alleviates LPS-induced hepatic oxidative stress and partially improves growth performance, potentially by suppressing a COX-2-associated NOX1-mediated pro-oxidant response and enhancing Nrf2/FoxO3/GPX1-dependent antioxidant defenses.

Indexed as

BroilersChlorogenic acidCyclooxygenase-2LipopolysaccharideOxidative damage

Identifiers

PMID42785059
PMCPMC13634714

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.