Evidence map›Paper›PMID 42785058›Full record

ArticlePoultry science2026

Transposable element insertion polymorphisms identify LOC101798742 as a candidate gene for breast muscle yield in ducks.

Weikang Ling, Cui He, Hong Tang, Yuan Bai, Yang Xi, Jingjing Qi, Shihao Guo, Zhao Yang, Xu Han, Anqi Huang and 4 more

Abstract read
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In one paragraph

Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Weikang LingState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, 611130, Chengdu, China; Farm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, 611130, Chengdu, China. Electronic address: 2025102018@stu.sicau.edu.cn.
Cui HeState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, 611130, Chengdu, China; Farm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, 611130, Chengdu, China. Electronic address: hetree2@163.com.
Hong TangState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, 611130, Chengdu, China; Farm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, 611130, Chengdu, China. Electronic address: 3309239165@qq.com.
Yuan BaiState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, 611130, Chengdu, China; Farm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, 611130, Chengdu, China. Electronic address: 1577702527@qq.com.
Yang XiCollege of Life Science, Sichuan Agricultural University, 625014, Ya'an, China. Electronic address: xiyang9596@163.com.
Jingjing QiState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, 611130, Chengdu, China; Farm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, 611130, Chengdu, China. Electronic address: 15512296736@163.com.
Shihao GuoState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, 611130, Chengdu, China; Farm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, 611130, Chengdu, China. Electronic address: guoshihao0@163.com.
Zhao YangState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, 611130, Chengdu, China; Farm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, 611130, Chengdu, China. Electronic address: 619797291@qq.com.
Xu HanState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, 611130, Chengdu, China; Farm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, 611130, Chengdu, China. Electronic address: kyuhi_xuhan@outlook.com.
Anqi HuangCollege of Life Science, Sichuan Agricultural University, 625014, Ya'an, China. Electronic address: huangaqii@sicau.edu.cn.
Shengqiang HuState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, 611130, Chengdu, China; Farm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, 611130, Chengdu, China. Electronic address: shenqiang.hu@sicau.edu.cn.
Chunchun HanState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, 611130, Chengdu, China; Farm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, 611130, Chengdu, China. Electronic address: chunchunhai_510@163.com.
Liang LiState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, 611130, Chengdu, China; Farm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, 611130, Chengdu, China. Electronic address: ll457@163.com.
Hehe LiuState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, 611130, Chengdu, China; Farm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, 611130, Chengdu, China; College of Life Science, Sichuan Agricultural University, 625014, Ya'an, China. Electronic address: Liuee1985@sicau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast muscle yield is an economically important trait in ducks, but the contribution of population-level transposable element insertion polymorphisms (TIPs) to its genetic regulation remains poorly understood. Whole-genome resequencing data from 200 ducks representing Cherry Valley ducks, Liancheng white ducks, and five Jinling White Duck lines were used to identify population-level TIPs. After quality filtering, TIP-based genome-wide association study (TIP-GWAS) and TIP-based expression genome-wide association study (TIP-eGWAS) were performed to identify loci associated with breast muscle traits and gene expression. Candidate genes were prioritized by integrating TIP-associated expression genes, weighted gene coexpression network analysis, differential expression analysis, and gene-trait correlation analysis, followed by functional evaluation in primary duck myoblasts. A total of 3,628 TIPs were identified, and 543 high-confidence TIPs were retained for population structure and association analyses. TIP-GWAS detected 14 significant trait-locus associations, mainly involving breast muscle yield traits, which were merged into 6 nonredundant TIP loci. Targeted TIP-eGWAS followed by conservative filtering retained 1,410 priority eGenes, of which 147 were associated with at least one target trait. These genes were enriched in pathways related to the tricarboxylic acid cycle, oxidative phosphorylation, carbon metabolism, fatty acid metabolism, and fibroblast growth factor receptor signaling. Integrative analysis prioritized LOC101798742 as a candidate gene corresponding to the chr6:36133712 TIP locus. In silico annotation indicated that LOC101798742 encodes the duck ortholog of alpha-aspartyl dipeptidase (DNPEP). In primary duck myoblasts, LOC101798742 knockdown reduced proliferation-related gene expression, altered cell-cycle distribution, and enhanced myoblast fusion, whereas overexpression promoted cell-cycle progression and increased apoptosis-related changes. These findings suggest that population-level TIP variation may contribute to duck breast muscle yield through gene regulatory networks and myoblast proliferation-differentiation dynamics. This study expands the range of regulatory variants considered in duck breeding and provides candidate loci and genes for future functional validation and genetic improvement.

Indexed as

Breast muscle yieldDuckMyoblast differentiationTransposable element insertion polymorphism

Identifiers

PMID42785058
PMCPMC13634756

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.