Evidence map›Paper›PMID 42784358›Full record

ArticleTropical medicine and infectious disease2026

Risk Factors for Poor Neurological Outcomes at Discharge in Tuberculous Meningitis: Disease Severity, Host Factors, and Drug Therapy.

Yuxia Yu, Huarui Liu, Huan Yang, Dan Ye, Lu Xia, Xiaoqing Ma, Jiayi Wang, Yuchong Sun, Feng Li, Yuanyuan Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tropical medicine and infectious disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuxia YuThe Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310000, China.ORCID 0009-0008-0097-5971
Huarui LiuCenter for Tuberculosis Research, Shanghai Public Health Clinical Center, Fudan University, Shanghai 200000, China.
Huan YangDepartment of Tuberculosis, Hangzhou Red Cross Hospital, Hangzhou 310000, China.
Dan YeCenter for Tuberculosis Research, Shanghai Public Health Clinical Center, Fudan University, Shanghai 200000, China.
Lu XiaCenter for Tuberculosis Research, Shanghai Public Health Clinical Center, Fudan University, Shanghai 200000, China.
Xiaoqing MaDepartment of Tuberculosis, Hangzhou Red Cross Hospital, Hangzhou 310000, China.
Jiayi WangThe Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310000, China.
Yuchong SunThe Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310000, China.
Feng LiCenter for Tuberculosis Research, Shanghai Public Health Clinical Center, Fudan University, Shanghai 200000, China.
Yuanyuan ChenDepartment of Tuberculosis, Hangzhou Red Cross Hospital, Hangzhou 310000, China.

Funding

Disease Prevention and Control Innovation Team of Zhejiang Province 2026JKC-05Hangzhou Key Scientific Research Program Project 2025SZD2B06the Clinical Research Plan Project of Traditional Chinese Medicine 2026ZL0580the Hangzhou Medical and Health Science and Technology Project A20262172the Major Project of Guangzhou National Laboratory GZNL2024A01030the Science and Technology Commission of Shanghai Municipality ZD2021CY001
6 · The paper itself

Abstract

introductionThis study investigated independent factors associated with neurological prognosis at discharge in patients with tuberculous meningitis (TBM) and evaluated the impact of intensified treatment regimens.

methodsA retrospective analysis was conducted in 518 TBM patients from two Chinese medical centers. LASSO and multivariable logistic regression were used to identify independent risk factors for poor neurological outcomes. A 1:1 PSM based on intensified treatment exposure was performed to assess its association with neurological outcomes, with an exploratory outcome-based matched comparison conducted for other prognostic factors.

resultsAmong 518 patients, 123 (23.75%) had poor neurological outcomes. The poor-prognosis group had higher proportions of MRC stage III (30.08% vs. 8.35%,

conclusionNeurological prognosis in TBM is influenced by both disease severity and host baseline status. Intensified therapy was not significantly associated with neurological outcome at discharge after adjustment, highlighting the importance of individualized risk management.

Indexed as

neurological outcomerisk factorstuberculous meningitis

Identifiers

PMID42784358
PMCPMC13611471

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.