ArticleNanomaterials (Basel, Switzerland)2026
Improving the Hydrophilicity of the Drugs Paclitaxel, Violacein, and Tetrandrine Using Carbon-Based Quantum Dots.
Christine Wu, Katherine Ayala, Solimar Collazo-Hernández, MiaSara Pérez-Salvá, Nataniel Medina-Berríos, Fabiola M Rosa-Suárez, Alondra Veloz-Bonilla, Rafael A Villanueva-Nogueras, Alexis Lavín Flores, Keyla A López-Pérez and 6 more
Abstract read
In one paragraphArticle in Nanomaterials (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
16 authors.
Katherine AyalaDepartment of Chemistry, Berea College, Berea, KY 40404, USA.
Solimar Collazo-HernándezDepartment of Biology, University of Puerto Rico-Río Piedras Campus, San Juan, PR 00925, USA.ORCID 0009-0003-9187-9742 MiaSara Pérez-SalváDepartment of Biology, University of Puerto Rico-Río Piedras Campus, San Juan, PR 00925, USA.ORCID 0009-0003-6622-6192 Nataniel Medina-BerríosDepartment of Chemistry, University of Puerto Rico-Río Piedras Campus, San Juan, PR 00925, USA.ORCID 0000-0002-4507-2687 Fabiola M Rosa-SuárezDepartment of Biology, University of Puerto Rico-Río Piedras Campus, San Juan, PR 00925, USA.
Alondra Veloz-BonillaDepartment of Biology, University of Puerto Rico-Río Piedras Campus, San Juan, PR 00925, USA.
Rafael A Villanueva-NoguerasDepartment of Biology, University of Puerto Rico-Río Piedras Campus, San Juan, PR 00925, USA.
Alexis Lavín FloresDepartment of Chemistry, University of Puerto Rico-Río Piedras Campus, San Juan, PR 00925, USA.
Keyla A López-PérezDepartment of Chemistry, University of Puerto Rico-Río Piedras Campus, San Juan, PR 00925, USA.ORCID 0009-0009-3067-1474 Valerie Ortiz-GómezSurgical Sciences Department, School of Dental Medicine, University Ana G. Méndez Gurabo Campus, Gurabo, PR 00777, USA.
Luis Prieto-CostasCenter for Tropical Biodiversity, Puerto Rico Science Trust, San Juan, PR 00936, USA.ORCID 0009-0003-1929-8935 Rafael Maldonado-HernándezDepartment of Biology, University of Puerto Rico-Cayey Campus, Cayey, PR 00736, USA.ORCID 0000-0003-1162-1614 Marvin J BayroDepartment of Chemistry, University of Puerto Rico-Río Piedras Campus, San Juan, PR 00925, USA.ORCID 0000-0003-1482-9381 Gerardo MorellDepartment of Physics, University of Puerto Rico-Río Piedras Campus, San Juan, PR 00925, USA.ORCID 0000-0003-4787-2239 Brad R WeinerDepartment of Chemistry, University of Puerto Rico-Río Piedras Campus, San Juan, PR 00925, USA.ORCID 0000-0002-5255-1918 Funding
SCIENCE AND TECHNOLOGY COMPETENCY & EDUCATION CORE (STCE)P20GM103475 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Jose R. Rodriguez-Medina · 2012 to 2026
$52.9MUpgrade Laboratories Facilities at UPR-Rio PiedrasR25GM061151 · NIGMS · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI CARBALLEIRA, NESTOR MANUEL · 2001 to 2023
$32.5MThe Role of Sensory Input to Mammalian Locomotion After the Loss of supraspinal.P20GM103642 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI LASALDE-DOMINICCI, JOSE ANTONIO · 2013 to 2023
$20.6MNASA 80NSSC22M0025NIGMS NIH HHS P20 GM103475NIGMS NIH HHS P20GM103475-20NIGMS NIH HHS P20 GM103642NIGMS NIH HHS R25 GM061151NIH HHS 5P20GM103642-11NIH HHS 5R25GM061151-20U.S. National Science Foundation 1626103U.S. National Science Foundation 2050493
6 · The paper itselfAbstract
Carbon-based quantum dots and their nitrogen- and sulfur-doped derivatives were used as platforms to improve the aqueous solubility for Paclitaxel, Violacein and Tetrandrine, drugs with known high partition coefficients (Log P). Paclitaxel, Violacein and Tetrandrine showed a significant reduction in their partition coefficient values by coupling with the carbon-based quantum dots. Paclitaxel's partition coefficient value decreased from 3.96 to 0.2, Violacein's from 3.34 to 1.17, and Tetrandrine's from 2.5 to 1.57, thus demonstrating a significant reduction in their hydrophobicity without being encapsulated. The efficiency of each type of carbon-based quantum dot in lowering each drug's Log P varied and this behavior was correlated with the nature of the surface interaction between each drug and each of the carbon-based quantum dots.
Indexed as
carbon-based quantum dothydrophobic drugpaclitaxelpartition coefficienttetrandrineviolacein
Identifiers
PMID42784175
PMCPMC13610360
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