Evidence map›Paper›PMID 42784131›Full record

ArticleNeurology international2026

Assessing Microstructural and Molecular Brain Changes in Early Cognitive Decline Using Multiparametric 3T Magnetic Resonance Imaging.

Zongpai Zhang, Jingpu Wu, Isabel M Rios Pulgar, Elizabeth H T Chang, Keyi Chai, Puyang Wang, Shanshan Jiang, Xu Li, Kenichi Oishi, Gwenn S Smith and 5 more

Abstract read
In one paragraph

Article in Neurology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zongpai ZhangDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0009-0008-3887-7031
Jingpu WuDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
Isabel M Rios PulgarDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
Elizabeth H T ChangDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0002-7201-946X
Keyi ChaiDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
Puyang WangDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0003-2657-6051
Shanshan JiangDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
Xu LiDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0002-4350-3375
Kenichi OishiDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0002-1200-8611
Gwenn S SmithDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
Carrie WagandtDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
Gregory M PontoneDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0002-9540-6913
Abhay MoghekarDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA.ORCID 0000-0001-9464-1551
Arnold BakkerDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0003-0417-641X
Jinyuan ZhouDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.

Funding

Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Corinne Pettigrew · 2020 to 2026
$29.3M
TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
Developing Protein-based MRI Biomarkers for Alzheimer's DiseaseR01AG069179 · NIA · JOHNS HOPKINS UNIVERSITY · PI ZHOU, JINYUAN · 2020 to 2024
$3.3M
Integrating circulating tumor DNA assay and protein-based MRI to accurately monitor glioma therapyR01CA276221 · NCI · JOHNS HOPKINS UNIVERSITY · PI CHETAN BETTEGOWDA, Shanshan Jiang · 2023 to 2026
$2.7M
Contribution of Cerebral Iron Load to Cognitive Function in Older Adults with High Risk to Develop Alzheimer's DiseaseR01AG063842 · NIA · JOHNS HOPKINS UNIVERSITY · PI LI, XU, QIAO, YE · 2020 to 2024
$2.5M
Quantitative CEST MRI for GBM Early Response Prediction and Biopsy GuidanceR37CA248077 · NCI · JOHNS HOPKINS UNIVERSITY · PI Shanshan Jiang · 2021 to 2026
$2.2M
NCI NIH HHS R01 CA276221NCI NIH HHS R37 CA248077NIA NIH HHS P30 AG066507NIA NIH HHS R01 AG063842NIA NIH HHS R01 AG069179NIBIB NIH HHS P41 EB031771NIH HHS 5P41EB031771-06NIH HHS 5R01AG063842-05NIH HHS 5R01AG069179-05NIH HHS 5R01CA276221-04NIH HHS 5R37CA248077-06
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer’s diseaseAPT imagingCEST imagingmicrostructural alterationmild cognitive impairmentmultiparametric MRI

Identifiers

PMID42784131
PMCPMC13610878

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.