ArticleMuscles (Basel, Switzerland)2026
Congenital Clubfoot as an Early Manifestation of Duchenne Muscular Dystrophy?
Article in Muscles (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
backgroundDuchenne muscular dystrophy (DMD) is the most common X-linked progressive neuromuscular disorder of childhood. The classic course of DMD is characterized by onset after a period of normal motor development. However, in recent years, evidence has been accumulating of prodromal features of the disease, including speech delays and neurocognitive impairments.
methodsThis study investigates whether congenital bilateral clubfoot may represent the first clinical manifestation of DMD.
resultsWe present two cases of male patients with congenital bilateral clubfoot who were subsequently diagnosed with DMD. We demonstrate the high efficacy and safety of the Ponseti method for correcting foot deformities in these patients. We discuss a possible pathogenic link between dystrophin deficiency and impaired intrauterine myogenesis.
conclusionsThis is the first report of an association between congenital clubfoot and DMD, highlighting the need for expanded early diagnostic protocols for boys presenting with idiopathic clubfoot.
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