Evidence map›Paper›PMID 42784050›Full record

ArticleMuscles (Basel, Switzerland)2026

Bilateral Muscle Architecture Differences in a Rabbit Model of Unilateral Hindlimb Transtibial Amputation: A Pilot Study.

Caleb Stubbs, Patrick T Hall, Allison J Nelson, Samantha Z Bratcher, Alicia A Matavosian, Cheryl B Greenacre, Bryce J Burton, Stacy M Stephenson, Remigiusz M Grzeskowiak, Alisha P Pedersen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Muscles (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Caleb StubbsDepartment of Biomedical Engineering, Tickle College of Engineering, University of Tennessee, Knoxville, TN 37996, USA.ORCID 0000-0002-9961-201X
Patrick T HallDepartment of Biomedical Engineering, Tickle College of Engineering, University of Tennessee, Knoxville, TN 37996, USA.
Allison J NelsonDepartment of Biomedical Engineering, Tickle College of Engineering, University of Tennessee, Knoxville, TN 37996, USA.ORCID 0000-0001-5874-7164
Samantha Z BratcherDepartment of Biomedical Engineering, Tickle College of Engineering, University of Tennessee, Knoxville, TN 37996, USA.
Alicia A MatavosianDepartment of Biomedical Engineering, Tickle College of Engineering, University of Tennessee, Knoxville, TN 37996, USA.
Cheryl B GreenacreCollege of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.
Bryce J BurtonCollege of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.
Stacy M StephensonDepartment of Surgery, Division of Plastic and Reconstructive Surgery, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920, USA.
Remigiusz M GrzeskowiakCollege of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.
Alisha P PedersenCollege of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.
Xiaojuan ZhuOffice of Innovative Technologies, University of Tennessee, Knoxville, TN 37996, USA.ORCID 0000-0003-2594-8968
David E AndersonCollege of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.ORCID 0000-0003-0745-7591
Dustin L CrouchDepartment of Biomedical Engineering, Tickle College of Engineering, University of Tennessee, Knoxville, TN 37996, USA.

Funding

Interdisciplinary Engineering Career Development Center in Movement and Rehabilitation SciencesK12HD073945 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DEWALD, JULIUS P, REINKENSMEYER, DAVID JAY · 2012 to 2021
$7.9M
NICHD NIH HHS K12 HD073945NIH HHS 5K12HD073945-08
6 · The paper itself

Abstract

Residual muscles after amputation experience mechanical unloading, loss of distal tendon insertion, and reduced excursion, conditions known to cause muscle degeneration. However, the architecture of residual muscles following amputation remains largely unreported. In this pilot, exploratory study, five healthy, skeletally mature, male New Zealand white rabbits underwent unilateral hind-paw ankle disarticulation. The contralateral intact limb served as the within-subject control. Six hindlimb muscles that cross the intact biological ankle were harvested bilaterally at four weeks post-amputation, and muscle mass, length, fiber length, pennation angle, sarcomere length, optimal fiber length (OFL), and physiologic cross-sectional area (PCSA) were measured. All statistical comparisons were based on raw, paired differences in values between sides. Muscle mass and OFL were, on average, lower on the residual side for all muscles; raw differences between sides were significant for mass of LG (

Indexed as

amputationmuscle architecturemuscle plasticityrabbit modelresidual limb

Identifiers

PMID42784050
PMCPMC13609715

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.