ReviewJournal of fungi (Basel, Switzerland)2026
Decision-Rule Architecture in Fungal Biomarker-Guided Antifungal Stewardship for Critically Ill Adults: A Systematic Review and
Giuseppe Neri, Giuseppe Mazza, Jessica Ielapi, Alessandro Russo, Francesca Serapide, Helenia Mastrangelo, Aldo Mesiti, Zaninni Caroleo, Stefano Fresilli, Andrea Bruni and 5 more
Abstract readReview
In one paragraphReview in Journal of fungi (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Giuseppe NeriDepartment of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0009-0003-2281-6529 Giuseppe MazzaDepartment of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0009-0003-9109-4929 Jessica IelapiDepartment of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0009-0009-8291-284X Alessandro RussoDepartment of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0000-0003-3846-4620 Francesca SerapideDepartment of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0000-0002-5555-3732 Helenia MastrangeloDepartment of Health Sciences, "Renato Dulbecco" University Hospital, 88100 Catanzaro, Italy.
Aldo MesitiDepartment of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0009-0000-3968-2561 Zaninni CaroleoDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.ORCID 0009-0002-1805-7921 Stefano FresilliDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.ORCID 0000-0003-0686-8700 Andrea BruniDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.
Simona GigliottiDepartment of Health Sciences, "Renato Dulbecco" University Hospital, 88100 Catanzaro, Italy.
Angela QuirinoDepartment of Health Sciences, "Renato Dulbecco" University Hospital, 88100 Catanzaro, Italy.
Giovanni MateraDepartment of Health Sciences, "Renato Dulbecco" University Hospital, 88100 Catanzaro, Italy.
Federico LonghiniDepartment of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0000-0002-6970-7202 Eugenio GarofaloDepartment of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0009-0000-0997-5267 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Fungal biomarkers may support antifungal stewardship in critically ill adults, but their clinical effect depends on the decision rule linking test results to treatment. We systematically reviewed ICU or ICU-relevant adult studies in which fungal biomarkers or rapid fungal diagnostics explicitly informed antifungal management. Searches were updated through 24 July 2026 (PROSPERO CRD420261432481), and clinically compatible
Indexed as
antifungal stewardshipCandidacritical caredecision rulefungal biomarkersmeta-analysisβ-(1→3)-D-glucan
Identifiers
PMID42783976
PMCPMC13608780
What OpenQuestion holds
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