Evidence map›Paper›PMID 42783921›Full record

ArticleMarine drugs2026

Isaridin E Attenuates Ischemic Brain Injury in Mice by Concurrently Reducing Platelet Hyperactivity and Microglial Neuroinflammation Associated with LRP1.

Yu-Chen Mi, Zi-Cheng Li, Qi-Qi Jiang, Lan Liu, Sen-Hua Chen, Ni Pan, Guan-Lei Wang

Abstract read
In one paragraph

Article in Marine drugs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yu-Chen MiDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Zi-Cheng LiDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Qi-Qi JiangDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Lan LiuSchool of Marine Sciences, Sun Yat-sen University, Zhuhai 519082, China.ORCID 0000-0003-2765-4015
Sen-Hua ChenSchool of Marine Sciences, Sun Yat-sen University, Zhuhai 519082, China.
Ni PanDepartment of Pharmacy, The Second Clinical College, Guangzhou Medical University, Guangzhou 510261, China.
Guan-Lei WangDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.ORCID 0000-0002-7947-1950

Funding

Natural Science Foundation of Guangdong Province 2024A1515010479Science and Technology Program of Guangzhou City 2025A04J4282
6 · The paper itself

Abstract

Isaridin E (ISE), a marine-derived fungal cyclodepsipeptide, possesses antiplatelet activity in vitro and antithrombotic efficacy in a FeCl

Indexed as

Blood PlateletsBrain IschemiaLow Density Lipoprotein Receptor-Related Protein-1MicrogliaNeuroinflammatory DiseasesNeuroprotective AgentsPlatelet Aggregation InhibitorsAnimalsCytokinesDisease Models, AnimalFungal ProteinsInfarction, Middle Cerebral ArteryMaleMiceMice, Inbred C57BLNF-kappa BCytokinesFungal Proteinsisaridin ELow Density Lipoprotein Receptor-Related Protein-1Lrp1 protein, mouseNeuroprotective AgentsNF-kappa BPeptides, CyclicPlatelet Aggregation InhibitorsIsaridin Eischemic strokemicroglial activationneuroinflammationplatelets

Identifiers

PMID42783921
PMCPMC13608163

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.