Organ-Resolved Metabolomics of

Guole Qin, Daizu Xie, Changqin Zhou, Delong Guan, Jing Song

Abstract read

In one paragraph

Article in Metabolites, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Guole QinGuangxi Key Laboratory of Sericulture Ecology and Intelligent Technology Application, Guangxi Collaborative Innovation Center of Modern Sericulture and Silk, Guangxi Colleges Universities Key Laboratory of Exploitation and Utilization of Microbial and Botanical Resources, School of Chemistry and Bioengineering, Hechi University, Hechi 546300, China.

Daizu XieHechi Forestry Research Institute, Hechi 547000, China.

Changqin ZhouZhongnong Qiaosheng (Fangchenggang) Traditional Chinese Medicine Technology Co., Ltd., Fangchenggang 538037, China.

Delong GuanGuangxi Key Laboratory of Sericulture Ecology and Intelligent Technology Application, Guangxi Collaborative Innovation Center of Modern Sericulture and Silk, Guangxi Colleges Universities Key Laboratory of Exploitation and Utilization of Microbial and Botanical Resources, School of Chemistry and Bioengineering, Hechi University, Hechi 546300, China.ORCID 0000-0001-6866-0943

Jing SongGuangxi Key Laboratory of Sericulture Ecology and Intelligent Technology Application, Guangxi Collaborative Innovation Center of Modern Sericulture and Silk, Guangxi Colleges Universities Key Laboratory of Exploitation and Utilization of Microbial and Botanical Resources, School of Chemistry and Bioengineering, Hechi University, Hechi 546300, China.ORCID 0000-0001-5314-9405

Funding

Hechi University 2023 Annual Operation Subsidy Project of the Guangxi Key Laboratory of Sericulture Ecology and Applied Intelligent Technology (23-026-08)Hechi University Hechi University high-level talent research start-up fee project (2021GCC017,2021GCC023)Hechi University Local Science and Technology Development Fund project guided by the central government (Heke ZY230301)

6 · The paper itself

Abstract

backgroundMATERIALS AND

methodsHere, untargeted LC-MS/MS metabolomics (UHPLC-Orbitrap) of methanol/acetonitrile/water extracts was applied to five organs of

resultsOrgan identity dominated the metabolic architecture of the sampled population: the first two principal components separated all five organs, with leaf and root as the two mutually opposed metabolic extremes and stem, young shoot and rhizome forming a contiguous module. Exploratory pairwise OPLS-DA combined with FDR-controlled univariate criteria yielded 193-1223 differentially accumulated metabolites per comparison, and tissue-specificity analysis assigned 2031 metabolites (73.45%) predominantly to a single organ. DISCUSSION: Metabolite accumulation patterns along the phenylpropanoid-flavonoid pathway was spatially partitioned, with flavan-3-ols and isoflavones accumulating in root, flavone/flavonol glycosides in leaf and predominantly hydroxycinnamic acids in rhizome and young shoot. Of 22 previously reported or candidate quality control constituents, putatively annotated terpenoid lactones were detected almost exclusively in the rhizome, whereas several phenolics showed markedly higher relative abundance in root or leaf.

conclusionsThese relative-abundance data indicate that the non-officinal organs are chemically complementary potential resources; absolute quantification, bioactivity and safety evaluation are prerequisites before any medicinal valorisation.

Indexed as

Cibotium barometzorgan-specific metabolite allocationphenylpropanoid–flavonoid biosynthesisquality control markerstissue specificity indexuntargeted metabolomics

Identifiers

PMID42783818

DOI10.3390/metabo16090693

PMCPMC13609080

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.