ReviewMetabolites2026
Folate: An Emerging Target in Type 2 Diabetes Mellitus and Its Complications.
Review in Metabolites, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
6 authors.
Funding
Abstract
Folate, which is also known as folic acid, vitamin B9, is a key coenzyme in one-carbon metabolism (OCM) and participates in nucleic acid synthesis, methylation, and redox regulation. In recent years, numerous studies have demonstrated its close association with type 2 diabetes mellitus (T2DM), gestational diabetes mellitus (GDM), and diabetic complications. Serum folate levels are decreased in patients with T2DM, which is associated with increased urinary excretion and metformin-mediated inhibition of folate absorption. The onset of GDM is characterized by a folate dose-dependent imbalance characteristic, high folate combined with vitamin B12 deficiency significantly increases the risk of GDM. Maternal folate status can also modulate offspring insulin sensitivity through epigenetic modifications. The mechanisms by which folate regulates diabetes mainly include lowering homocysteine (Hcy) concentrations, suppressing oxidative stress and inflammatory responses, modulating OCM, and mediating DNA methylation modifications. Cumulative evidence-based data indicate that appropriate folic acid supplementation can improve insulin resistance, restore vascular endothelial function, reduce the risk of cardiovascular diseases (CVDs), diabetic peripheral neuropathy, retinopathy, cognitive impairment, and other complications, and alleviate damage induced by high glucose. This review systematically summarizes the roles and molecular mechanisms of folate in diabetes and its complications, highlighting folate as a potential intervention target for diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.