Evidence map›Paper›PMID 42783765›Full record

ArticleMetabolites2026

Circulating Metabolites Associated with Prothrombin Time in Children with Congenital Heart Disease: An Untargeted Metabolomics Study.

Shengxu Li, Dave Watson, Alissa Jorgenson, Zainab Adelekan, Kathleen Garland, Benjamin Deonovic, Leah Burns, Weihong Tang, David M Overman, Marnie T Huntley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shengxu LiChildren's Minnesota Research Institute, Children's Minnesota, Minneapolis, MN 55404, USA.ORCID 0000-0001-9210-7283
Dave WatsonChildren's Minnesota Research Institute, Children's Minnesota, Minneapolis, MN 55404, USA.ORCID 0000-0002-2749-6136
Alissa JorgensonClinical and Translational Science Institute, University of Minnesota, Minneapolis, MN 55414, USA.
Zainab AdelekanChildren's Minnesota Research Institute, Children's Minnesota, Minneapolis, MN 55404, USA.
Kathleen GarlandHematology and Oncology, Children's Minnesota, Minneapolis, MN 55404, USA.
Benjamin DeonovicChildren's Minnesota Research Institute, Children's Minnesota, Minneapolis, MN 55404, USA.
Leah BurnsThe Children's Heart Clinic, Minneapolis, MN 55404, USA.
Weihong TangDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA.
David M OvermanCardiovascular and Critical Care Research Center, Children's Minnesota, Minneapolis, MN 55404, USA.
Marnie T HuntleyThe Children's Heart Clinic, Minneapolis, MN 55404, USA.ORCID 0009-0000-3758-4001

Funding

Children's Minnesota Research Committee N/A
6 · The paper itself

Abstract

backgroundCoagulation markers are used to guide clinical anticoagulation decisions. We aimed to identify circulating metabolites that are associated with coagulation markers in children with congenital heart disease (CHD).

methodsPlasma samples were separated from whole blood under consistent conditions. Untargeted metabolomic data were measured in plasma from up to 203 young patients (age range: 0 days-24 years) with CHD before cardiac surgery. Coagulation markers included activated partial thromboplastin time (aPTT), prothrombin time (PT), and activated clotting time (ACT). Weighted Gene Co-expression Network Analysis (WGCNA) was performed to explore metabolite modules (clusters). Associations of metabolites with the coagulation markers were assessed cross-sectionally with regression models, with false discovery rate (FDR) correction for multiple comparison. Associations between coagulation markers and "eigenmetabolites" from WGCNA modules were assessed by correlation analysis.

resultsA total of 776 metabolites were included in the final analysis. Among these, 20 metabolites were associated with PT and one (valine) with ACT (FDR q value < 0.05). Among the metabolites associated with PT, the top three were retinol, 1-palmitoyl-GPI (16:0), and X-25371 (identity unknown). One module from WGCNA with metabolites from the lipid super pathway was correlated with PT (

conclusionsIn this first attempt to identify novel metabolites for coagulation markers, we report 21 metabolites associated with PT or ACT in children with CHD. Future studies are needed to replicate these findings in independent cohorts and to elucidate the biological mechanisms linking these metabolites to hemostatic regulation.

Indexed as

blood coagulationcongenital heart defectsmetabolomicspediatrics

Identifiers

PMID42783765
PMCPMC13609389

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.