Evidence map›Paper›PMID 42783748›Full record

ArticleMetabolites2026

Sex-Associated Effects of Thioredoxin Reductase Inhibition in Hyperoxia-Induced Lung Injury in Adult Mice.

Katelyn Dunigan-Russell, Matthew Ryan Smith, Hua Zhong, ViLinh Tran, Dean P Jones, Lynette K Rogers, Trent Tipple

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katelyn Dunigan-RussellNeonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Matthew Ryan SmithAtlanta VA Healthcare System, Decatur, GA 30033, USA.ORCID 0000-0002-8889-3477
Hua ZhongDepartment of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
ViLinh TranDivision of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, GA 30322, USA.
Dean P JonesDivision of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, GA 30322, USA.
Lynette K RogersDepartment of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Trent TippleDepartment of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

Funding

Targeting Thioredoxin Reductase-1 to Prevent Bronchopulmonary DysplasiaR01HL119280 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TIPPLE, TRENT · 2014 to 2018
$2.0M
American Thoracic SocietyBLRD VA IK2 BX005913National Heart Lung and Blood Institute R01HL119280NHLBI NIH HHS R01 HL119280United States Department of Veterans Affairs 1IK2BX005913-01A2
6 · The paper itself

Abstract

backgroundSupraphysiological levels of oxygen are often used as therapy for acute respiratory distress and severe pulmonary morbidities but can cause excessive generation of reactive oxygen species resulting in oxidative and inflammatory injury. Aurothioglucose (ATG), an FDA-approved, gold-containing pharmaceutical, potently and irreversibly inhibits thioredoxin reductase 1, and ATG treatment preserves reduced glutathione levels and attenuates hyperoxic lung injury.

methodsAdult C3H mice were treated with saline or ATG and exposed to room air (RA) or >95% O

resultsIn <95% O

conclusionsThe current data suggest that the improved survival of hyperoxia-exposed, ATG-treated, female C3H mice may be driven by alterations in glutathione synthesis, energy production, and metabolism resulting in decreased lung injury. These findings may provide direction for further research to improve outcomes after hyperoxia exposure.

Indexed as

aurothioglucosehyperoxialungmetabolomicssex differences

Identifiers

PMID42783748
PMCPMC13609309

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.