Evidence map›Paper›PMID 42783738›Full record

ArticleMetabolites2026

Live-Cell Optical Redox Imaging Reveals Metabolic Heterogeneity and Context-Dependent Responses to Metabolic Perturbation in TNBC Cells.

He N Xu, Jack Kollmar, Allison Podsednik, Mihiar Wannousse, Alexander Shestov, Roddy S O'Connor, Joseph A Baur, Julia Tchou, Rong Zhou, Lin Z Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

He N XuDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-5127-2629
Jack KollmarDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Allison PodsednikDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-7202-0906
Mihiar WannousseDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Alexander ShestovCenter for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Roddy S O'ConnorCenter for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Joseph A BaurDepartment of Physiology, Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Julia TchouDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Rong ZhouDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lin Z LiDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-9447-7982

Funding

Targeting NAD Metabolism to Improve Glucose Homeostasis in Obesity and AgingR01DK098656 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Joseph A. Baur · 2013 to 2026
$6.1M
Redox imaging for breast cancer prognosisR01CA191207 · NCI · UNIVERSITY OF PENNSYLVANIA · PI LI, LIN Z · 2015 to 2019
$3.2M
Understanding the roles of cardiac NAD pools and therapeutic effects of precursor supplements in heart failureR01HL165792 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BAUR, JOSEPH A. · 2022 to 2025
$2.7M
Label-Free Optical Redox Imaging for Pretreatment Prognosis of Early-Stage Triple Negative Breast CancerR01CA277037 · NCI · UNIVERSITY OF PENNSYLVANIA · PI LIN Z LI · 2023 to 2026
$2.6M
PET Imaging of Glutamine Metabolism and Glutamate Transport to Guide Metabolically Targeted Therapy in Triple-Negative Breast CancerR01CA266285 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DAVID A. MANKOFF, Rong Zhou · 2022 to 2026
$2.6M
What fuels CAR T-cell serial killingR01CA278837 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Roderick O'Connor · 2023 to 2026
$1.3M
Translational Imaging Markers for Metabolic Potentiation of ImmunotherapyR01CA301356 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DAVID A. MANKOFF, Rong Zhou · 2026 to 2026
$674k
EXON20-IRC EXON20-IRCLudwig Research Foundation Princeton Branch Ludwig Research Foundation Princeton BranchNational Heart Lung and Blood Institute R01 HL165792NCI NIH HHS R01 CA191207NCI NIH HHS R01 CA266285NCI NIH HHS R01 CA277037NCI NIH HHS R01 CA278837NCI NIH HHS R01 CA301356NHLBI NIH HHS R01 HL165792NIDDK NIH HHS R01 DK098656NIH HHS 1R01CA191207-05NIH HHS 1R01CA277037-05NIH HHS 1R01CA278837-05The Bruder Family Breast Cancer Immunotherapy Research Funds The Bruder Family Breast Cancer Immunotherapy Research FundsUniversity of Pennsylvania Thomas B. McCabe and Jeannette E. Laws McCabe Fund Pilot Award
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ECARFADglutaminolysisglycolysismitochondrial redox stateNADHOCRORRROSwide-field metabolic imaging microscopy

Identifiers

PMID42783738
PMCPMC13609622

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.