Evidence map›Paper›PMID 42783701›Full record

ArticleJournal of functional biomaterials2026

Enhanced Efficacy of Sandblasted, Large-Grit, Alkaline-Etched (SLA) Titanium Surfaces Combined with Plasma Treatment and Secretory Leukocyte Protease Inhibitor (SLPI) Coating in Promoting Osteoblast Activity and Reducing Bacterial Adhesion.

Wannapat Chouyratchakarn, Nattikan Thongjui, Chayanisa Phutiyothin, Onnicha Srisopar, Surasak Tangkamonsri, Chakrit Wiboonsuntharangkoon, Pakorn Sang-Ngam, Norrapon Vichiansan, Nithi Atthi, Chayarop Supanchart and 1 more

Abstract read
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In one paragraph

Article in Journal of functional biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wannapat ChouyratchakarnBiomedical Engineering Institute, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0002-6727-7210
Nattikan ThongjuiBiomedical Engineering Institute, Chiang Mai University, Chiang Mai 50200, Thailand.
Chayanisa PhutiyothinBiomedical Engineering Institute, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0003-4246-8560
Onnicha SrisoparBiomedical Engineering Institute, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0009-0009-2849-3314
Surasak TangkamonsriBiomedical Engineering Institute, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0009-0009-2666-6883
Chakrit WiboonsuntharangkoonBiomedical Engineering Institute, Chiang Mai University, Chiang Mai 50200, Thailand.
Pakorn Sang-NgamBiomedical Engineering Institute, Chiang Mai University, Chiang Mai 50200, Thailand.
Norrapon VichiansanCenter of integrated Engineering, Faculty of Engineering, Chiang Mai University, Chiang Mai 50200, Thailand.
Nithi AtthiThai Microelectronics Center (TMEC), National Science and Technology Development Agency (NSTDA), Pathum Thani 12120, Thailand.
Chayarop SupanchartBiomedical Engineering and Innovation Research Center, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0003-1894-8863
Sarawut KumphuneBiomedical Engineering Institute, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0003-4940-7103

Funding

Chiang Mai UniversityChiang Mai University R68IN0067National Research Council of Thailand NRCT: 214460
6 · The paper itself

Abstract

The clinical success rate of titanium (Ti) implants is significantly reduced in elderly patients and by implant-associated bacterial infections. Thus, Ti surfaces were modified using sandblasted large-grit alkaline etching (SLA), argon-nonthermal plasma treatment, and recombinant human secretory leukocyte protease inhibitor (rhSLPI) coating. This study evaluated surface characteristics, human fetal osteoblast (hFOB 1.19) activities, and antibacterial efficacy. The modified surfaces exhibited increased roughness and hydrophilicity compared to Ti. The SBPTi-rhSLPI enhanced 7-day protein retention on the surface. While Ti promoted higher cell proliferation, the modified groups demonstrated superior cell adhesion and mineralization. Specifically, SBPTi-rhSLPI showed the highest cytoplasmic spreading, adhesion-related gene expression (

Indexed as

bacterial adhesioncell adhesioncell differentiationosteoblastsplasma treatmentsandblast, large-grit, and alkaline etching (SLA)secretory leukocyte protease inhibitor (SLPI)surface modificationssurface properties

Identifiers

PMID42783701
PMCPMC13608177

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.