ArticleJournal of functional biomaterials2026
Enhanced Osteoinduction, Rheological and Mechanical Performance of 3D-Printed Methylcellulose-Gelatin-Hydroxyapatite Scaffolds.
Article in Journal of functional biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Complex patient-specific bone defects remain difficult to reconstruct because the regenerative capacity of bone is limited and prefabricated implants cannot readily match defect geometry. In this work, methylcellulose-gelatin-hydroxyapatite (MC/GEL/HA) inks were formulated with varying methylcellulose content and hydroxyapatite incorporation, crosslinked with EDC/NHS, and 3D-printed into porous scaffolds with defined square-pore architectures. Inks were evaluated by oscillatory and steady-shear rheology, and printed scaffolds were characterized for morphology, chemical composition, mechanical performance, physicochemical stability, wettability, apatite-forming bioactivity, and osteogenic responses of human bone marrow mesenchymal stem cells. Methylcellulose content primarily governed ink rheology and printability, and increased compressive strength (up to ~0.38 MPa for 15MC/10GEL/30HA), whereas hydroxyapatite enhanced surface hydrophilicity, promoted apatite nucleation within 7 days in simulated body fluid, and markedly increased alkaline phosphatase activity (>10-fold over HA-free scaffolds), mineralization (~2-fold by Alizarin Red), and the highest osteocalcin expression among the HA-containing formulations (~2.45-fold at day 14). The 15MC/10GEL/30HA formulation showed the most favorable balance of printability, mechanical performance, and osteogenic performance. These complementary functions reconciled structural stability with osteogenic performance, supporting the MC/GEL/HA system as a tunable bioink platform for non-weight-bearing bone regeneration, while warranting further in vivo validation.
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