Evidence map›Paper›PMID 42783594›Full record

ArticleJournal of market access & health policy2026

Real-World Shelf Life of Epinephrine Auto-Injectors in Canada: Implications for Renewal Frequency and Patient Burden.

John Papastergiou, Mille Vang Lybech, Christoffer Mertz, Anne Danø, Jess Finney, David Grabowski

Abstract read
In one paragraph

Article in Journal of market access & health policy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

John PapastergiouLeslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.ORCID 0000-0002-5475-0929
Mille Vang LybechALK-Abelló, 2970 Hørsholm, Denmark.
Christoffer MertzEviproseon, 4320 Lejre, Denmark.ORCID 0000-0001-7186-2116
Anne DanøInspiria, 2960 Rungsted Kyst, Denmark.ORCID 0000-0003-2051-5186
Jess FinneyBranding Science Group, London SW18 1DE, UK.ORCID 0009-0007-7182-5244
David GrabowskiALK-Abelló Pharmaceuticals Inc., Mississauga, ON L4Z 2H6, Canada.

Funding

ALK-Abelló (Denmark)
6 · The paper itself

Abstract

Although patients in Canada at risk of anaphylaxis are recommended to maintain access to two in-date epinephrine auto-injectors (EAIs) at all times, underuse during emergencies remains common. Multiple factors contribute to this gap, but the impact of real-world shelf life has been understudied. This study examines the remaining in-pharmacy shelf life of EAIs in Canada and considers its potential implications for patient burden, renewal frequency, and anaphylaxis preparedness. In this cross-sectional study, 50 licensed Canadian pharmacists from chain, independent, grocery/mass merchandise, and hospital pharmacies completed an online questionnaire and assessed EAI stock. Participating pharmacists verified all EAI stock on site, including batch numbers and expiry dates, and reported patient disposal practices. Of the 50 participating pharmacists, 49 reported 411 EAI devices across 98 batches. The mean in-pharmacy shelf life at dispensing was 12.8 months, with 47.4% of devices having 12 months or less remaining shelf life. Disposal practices varied and expiry was the most cited reason for disposal. Shortened in-pharmacy shelf life may increase renewal frequency, cost, waste, and the risk that patients carry expired devices or no device during anaphylaxis. Longer-shelf-life epinephrine treatment options or improved distribution chain practices may help reduce patient burden and enhance anaphylaxis preparedness in Canada.

Indexed as

anaphylaxis treatmentdisposal practicesepinephrine auto-injectorsexpirypharmacy inventory managementshelf life

Identifiers

PMID42783594
PMCPMC13608879

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.