ArticleInsects2026
Metabolic Reprogramming Supports Neonicotinoid Resistance in the Brown Planthopper,
Article in Insects, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Metabolic resistance is commonly attributed to the overexpression of detoxification enzymes, whereas the metabolic systems that sustain detoxification remain less well resolved. Here, we integrated widely targeted metabolomics and transcriptomics to compare the clothianidin-resistant brown planthopper strain CLR with the susceptible strain CLS and validated candidate genes in an independent nitenpyram-resistant background. CLR and CLS exhibited distinct metabolomic profiles. Differential genes and metabolites converged on carbon metabolism, glycolysis/gluconeogenesis, the tricarboxylic acid cycle, glutathione metabolism, pentose and glucuronate interconversions, cytochrome P450-mediated xenobiotic metabolism, and ABC transporters. These changes were summarized into four interconnected modules involving glycolytic energy supply, protective sugar-derived metabolites, pyruvate-TCA-malate metabolism, and UGT-mediated glycosylation. Expression analysis identified a mitochondrial NADP-dependent isocitrate dehydrogenase gene and UDP-glucosyltransferase 2 (UGT2) as consistently upregulated in both resistant backgrounds. Silencing
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