ArticleDiseases (Basel, Switzerland)2026
Mechanisms of Mitral Valve Repair Failure in a Redo Cohort: Association with Patient Characteristics and Initial Repair Features.
Article in Diseases (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMitral valve repair failure encompasses heterogeneous anatomical patterns requiring redo surgery, yet the factors determining why repaired valves fail through different mechanisms remain poorly understood. We investigated the association of patient characteristics and index repair features with the anatomical mechanisms of failure among patients requiring redo surgery after degenerative mitral valve repair.
methodsWe retrospectively reviewed all consecutive patients undergoing redo mitral valve surgery after previous degenerative mitral valve repair between January 2010 and June 2026. To minimize misclassification bias, only patients with complete operative documentation of the index repair and detailed intraoperative information regarding the mechanism of repair failure were included. Operative reports were reviewed to identify the reconstructive techniques used during the initial repair and the anatomical mechanism of failure at reoperation. To account for mutually exclusive clinical outcomes (prolapse recurrence and mitral stenosis), a competing-risks framework was employed.
resultsA total of 121 patients constituted the study cohort. Recurrent leaflet prolapse was the most frequent mechanism of repair failure (71.6%) among patients with mitral regurgitation; mitral stenosis was present in 27.3% overall. Leaflet preservation versus resection, implantation of expanded polytetrafluoroethylene (ePTFE) neochordae, edge-to-edge repair, and annuloplasty ring size were not significantly associated with the anatomical mechanism of repair failure. In multivariable analysis, older age at the index operation was independently associated with recurrent prolapse, whereas younger age and female sex independently predicted the development of mitral stenosis. Within this redo cohort, no statistically significant association was observed between the recorded index repair features and the predominant anatomical mechanisms of failure after adjustment for patient characteristics.
conclusionsAmong patients requiring redo surgery after degenerative mitral valve repair, the anatomical mechanisms of failure were associated with selected patient characteristics, whereas no significant association was observed with the recorded index repair features. These findings should be interpreted within the context of a selected redo population and do not support conclusions regarding the comparative durability of different repair strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.