Periodontal Disease Diagnosis by a Chemically Etched Single-Mode Fiber-Optic Biosensor for Label-Free Detection of Matrix Metalloproteinase-8 (MMP-8).

Rigoberto Tovar, Sarkis Sozkes, Marzhan Sypabekova

Abstract read

In one paragraph

Article in Biosensors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rigoberto TovarDepartment of Bioengineering, Civil Engineering, and Environmental Engineering, U. A. Whitaker College of Engineering, Florida Gulf Coast University, 10501 FGCU Boulevard South, Fort Myers, FL 33965, USA.

Sarkis SozkesDepartment of Bioengineering, Civil Engineering, and Environmental Engineering, U. A. Whitaker College of Engineering, Florida Gulf Coast University, 10501 FGCU Boulevard South, Fort Myers, FL 33965, USA.ORCID 0000-0003-1555-3591

Marzhan SypabekovaDepartment of Bioengineering, Civil Engineering, and Environmental Engineering, U. A. Whitaker College of Engineering, Florida Gulf Coast University, 10501 FGCU Boulevard South, Fort Myers, FL 33965, USA.ORCID 0000-0002-6423-3781

Funding

Head Start Grant from the U. A. Whitaker College of Engineering, Florida Gulf Coast University, 2025-2026.

6 · The paper itself

Abstract

A miniature label-free biosensor based on a chemically etched single-mode optical fiber (SMF) is reported for the detection of matrix metalloproteinase-8 (MMP-8), a salivary biomarker of active periodontitis with a clinical decision threshold of 20 ng/mL. Fibers etched in 48% hydrofluoric acid to a waist diameter of 16.0 ± 1.4 µm gave a mean refractive index (RI) sensitivity of 376.8%/RIU and an RI limit of detection (LOD) of 5.9 × 10

Indexed as

Biosensing TechniquesFiber Optic TechnologyMatrix Metalloproteinase 8Periodontal DiseasesBiomarkersHumansLimit of DetectionOptical FibersSalivaBiomarkersMatrix Metalloproteinase 8etched single-mode fiberevanescent wavelabel-free detectionMMP-8optical fiber biosensorperiodontal diseasepoint-of-care diagnosticsspiked saliva

Identifiers

PMID42783158

DOI10.3390/bios16090491

PMCPMC13604195

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.