Simulation-Based Microfluidic Deformation Mapping for Region-Dependent Apparent Young's Modulus Estimation of Single Cells.

Minhui Liang, Yilong Zhou, Dawei Ming, Jiawei Lyu, Jianwei Zhong, Han Li, Lin Lin

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Article in Biosensors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Minhui LiangSchool of Mechanical Engineering, Guangxi University, Nanning 530004, China.ORCID 0000-0003-2577-2405

Yilong ZhouSchool of Mechanical Engineering, Guangxi University, Nanning 530004, China.

Dawei MingSchool of Mechanical Engineering, Guangxi University, Nanning 530004, China.

Jiawei LyuSchool of Mechanical Engineering, Guangxi University, Nanning 530004, China.

Jianwei ZhongSchool of Microelectronics, South China University of Technology, Guangzhou 511442, China.ORCID 0000-0001-6198-868X

Han LiThe People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning 530021, China.

Lin LinSchool of Mechanical Engineering, Guangxi University, Nanning 530004, China.ORCID 0000-0001-7853-2558

Funding

National Natural Science Foundation of China 62501242National Natural Science Foundation of Guangxi Province 2026GXNSFBA00640439Natural Science Foundation of Guangxi Zhuang 636 Autonomous Region 2023GXNSFBA026214Natural Science Foundation of Guangxi Zhuang 636 Autonomous Region 2026GXNSFAA00641106

6 · The paper itself

Abstract

High-throughput microfluidic deformation assays enable label-free single-cell mechanophenotyping by quantifying how cells deform under controlled hydrodynamic loading. These approaches commonly extract deformation-related observables, such as projected area, axis ratio, and deformation index, and use them as indicators for cellular mechanical properties. However, deformation is not solely determined by stiffness; it is a coupled outcome of cell size, local hydrodynamic stress, and intrinsic mechanical response. Therefore, we present a simulation-based microfluidic framework for estimating region-dependent apparent Young's modulus (

Indexed as

Elastic ModulusMicrofluidicsSingle-Cell AnalysisComputer SimulationHumansHydrodynamicsK562 CellsMicrofluidic Analytical Techniquesdeformability cytometryhydrodynamic deformationmicrofluidicsnumerical simulationsingle-cell mechanophenotypingYoung’s modulus

Identifiers

PMID42783128

DOI10.3390/bios16090461

PMCPMC13604120

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.