Evidence map›Paper›PMID 42783035›Full record

ArticleJournal of cardiovascular development and disease2026

Endothelial Filamin C Alleviates Atherosclerosis via PINK1/Parkin-Dependent Mitophagy and mtDNA-cGAS-STING Inflammation Suppression.

Yongxuan Zhan, Yan Feng, Ting Zhao, Jiapeng Fu, Minghui Chen, Mingli Liu, Yu Cao, Jiaju Li, Xiangqi Meng, Yongli Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular development and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yongxuan ZhanDepartment of Neurosurgery, The Second Clinical Medical College, Harbin Medical University, Harbin 150086, China.
Yan FengDepartment of Neurosurgery, The Second Clinical Medical College, Harbin Medical University, Harbin 150086, China.
Ting ZhaoDepartment of Neurosurgery, The Second Clinical Medical College, Harbin Medical University, Harbin 150086, China.
Jiapeng FuDepartment of Neurosurgery, The Second Clinical Medical College, Harbin Medical University, Harbin 150086, China.
Minghui ChenDepartment of Neurosurgery, The Second Clinical Medical College, Harbin Medical University, Harbin 150086, China.
Mingli LiuDepartment of Neurosurgery, The Second Clinical Medical College, Harbin Medical University, Harbin 150086, China.
Yu CaoDepartment of Neurosurgery, The Second Clinical Medical College, Harbin Medical University, Harbin 150086, China.
Jiaju LiDepartment of Neurosurgery, The Second Clinical Medical College, Harbin Medical University, Harbin 150086, China.
Xiangqi MengDepartment of Neurosurgery, The Second Clinical Medical College, Harbin Medical University, Harbin 150086, China.ORCID 0000-0001-9550-6087
Yongli LiDepartment of Neurosurgery, The Second Clinical Medical College, Harbin Medical University, Harbin 150086, China.

Funding

Beijing Kanghua Foundation for the Development of Traditional Chinese and Western Medicine 070500020557(2023)Central-guided local science and technology development fund project (free exploration type basic research) 246Z7775GNational Natural Science Foundation of China 82272988
6 · The paper itself

Abstract

Endothelial dysfunction and impaired mitophagy represent core pathological drivers of atherosclerosis progression, yet upstream molecular regulators governing this process in vascular endothelium remain largely uncharacterized. This study delineated the functional role and mechanistic basis of filamin C (FLNC) in atherosclerosis-related endothelial injury. We profiled FLNC expression in 20 paired human carotid plaque and adjacent normal vascular tissues collected from patients undergoing carotid endarterectomy. In vitro, CRISPRa/CRISPRi-stable HUVEC lines were challenged with ox-LDL, with pharmacological (Mdivi-1) and genetic (si-PINK1/si-Parkin) rescue assays used to verify causal signaling. In vivo, Tie2-driven endothelial-specific FLNC-overexpressing ApoE

Indexed as

atherosclerosiscGAS-STING pathwayFLNCmitophagyPINK1/Parkin pathway

Identifiers

PMID42783035
PMCPMC13607726

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.