ArticleJournal of cardiovascular development and disease2026
Monocyte-to-High-Density-Lipoprotein Ratio Is Associated with Ventricular Arrhythmia in Patients with Implantable Cardioverter-Defibrillators: A Cross-Sectional Study.
Article in Journal of cardiovascular development and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundResidual arrhythmic risk persists in recipients of implantable cardioverter-defibrillators (ICDs) despite guideline-based selection, and inexpensive markers that refine this risk are needed. The monocyte-to-high-density-lipoprotein ratio (MHR) integrates a pro-inflammatory (monocyte) and an anti-inflammatory/antioxidant (HDL) signal in a single index derived from routine blood work. We examined whether MHR is associated with ventricular arrhythmia in ICD patients.
methodsIn this cross-sectional study we assessed 382 ICD recipients attending a device outpatient clinic and classified them by a composite ventricular arrhythmia outcome (non-sustained ventricular tachycardia, sustained ventricular tachycardia, or ventricular fibrillation) documented on device interrogation. MHR and comparator inflammatory markers were measured at the same visit. Discrimination was assessed by receiver operating characteristic (ROC) analysis, the optimal threshold by the Youden index, and independence by multivariable logistic regression; internal validity was examined with repeated cross-validation, bootstrap optimism correction, and calibration testing.
resultsThe ventricular arrhythmia outcome was present in 58 patients (15.2%). MHR was higher in patients with the outcome (median 16.3 vs. 12.3,
conclusionsMHR is independently associated with documented ventricular arrhythmia in ICD patients and, being derived from routine tests, may warrant prospective evaluation as a low-cost adjunct for risk stratification.
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