Microvascular Disease in the Hippocampus in Obstructive Sleep Apnoea.

Cuicui Xu, Jessica E Owen, Thorarinn Gislason, Bryndís Benediktsdóttir, Jiming Ye, Stephen R Robinson

Abstract read

In one paragraph

Article in Clocks & sleep, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cuicui XuSchool of Health and Biomedical Sciences, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, VIC 3083, Australia.ORCID 0000-0001-5345-8697

Jessica E OwenSchool of Health and Biomedical Sciences, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, VIC 3083, Australia.ORCID 0000-0003-3318-9914

Thorarinn GislasonDepartment of Sleep, Landspitali-The National University Hospital of Iceland, 101 Reykjavik, Iceland.

Bryndís BenediktsdóttirDepartment of Sleep, Landspitali-The National University Hospital of Iceland, 101 Reykjavik, Iceland.

Jiming YeSchool of Health and Biomedical Sciences, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, VIC 3083, Australia.ORCID 0000-0003-3983-0098

Stephen R RobinsonSchool of Health and Biomedical Sciences, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, VIC 3083, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemia is a primary cause of microvascular disease, particularly in the hippocampus, which is unusually vulnerable to hypoperfusion and hypoxia. Since intermittent hypoxia is a defining feature of obstructive sleep apnoea (OSA), the present study examined microvessels in autopsy tissue from patients with clinically confirmed OSA. Immunohistochemistry was performed on 30 hippocampal autopsy samples to investigate whether the incidence of microvascular abnormalities is associated with increased OSA severity, and if so, whether regular use of continuous positive airway pressure (CPAP) is protective. There were significantly more string vessels (4.3 ± 0.9 vs. 1.7 ± 0.4,

Indexed as

ageingblood flowcapillaryCPAPintermittent hypoxiaischemiaoxidative stress

Identifiers

PMID42783004

DOI10.3390/clockssleep8030051

PMCPMC13605731

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.