Pretreatment Ki67-to-ADC Ratio Predicts Prognosis in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy: A Retrospective Cohort Study.

Jun Fan, Lin Lin, Yang Tao, Yanjia Fan, Yudi Jin, Fajin Lv

Abstract read

In one paragraph

Article in Current oncology (Toronto, Ont.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

6 authors.

Jun FanDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Lin LinDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.ORCID 0009-0002-8221-4055

Yang TaoDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Yanjia FanDepartment of Breast and Thyroid Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Yudi JinDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Fajin LvDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.ORCID 0000-0002-6484-9738

Funding

the First Affiliated Hospital of Chongqing Medical University CYYY-BSYJSKYCXXM202412

6 · The paper itself

Abstract

(1) Background: Neoadjuvant chemotherapy (NAC) is important for breast cancer, but prognosis varies widely. Ki67 and apparent diffusion coefficient (ADC) reflect proliferation and cellularity, respectively. This study evaluated the prognostic value of the Ki67/ADC ratio (KA) and post-treatment ADC change (δADC) in breast cancer patients receiving NAC, and developed a survival prediction model incorporating these indicators. (2) Methods: Two cohorts of breast cancer patients treated with NAC were collected. Pre- and post-treatment breast MRI with diffusion-weighted imaging were obtained; ADC values were measured by two blinded radiologists. KA was calculated as pre-treatment Ki67 divided by pre-treatment ADC, and δADC as post-ADC minus pre-ADC. Disease-free survival (DFS) was the primary outcome. Cox regression and a predictive Cox model were used. (3) Results: A total of 419 patients were analyzed. Both KA and δADC were associated with survival. In multivariable analysis, KA remained an independent prognostic factor (HR 0.40, 95% CI 0.19-0.84,

Indexed as

Breast NeoplasmsKi-67 AntigenNeoadjuvant TherapyAdultAgedDiffusion Magnetic Resonance ImagingFemaleHumansMiddle AgedPrognosisRetrospective StudiesKi-67 AntigenADCbreast cancerKi67neoadjuvant chemotherapypredictive modelprognosisδADC

Identifiers

PMID42782881

DOI10.3390/curroncol33090534

PMCPMC13605751

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.