Evidence map›Paper›PMID 42782872›Full record

ArticleCurrent oncology (Toronto, Ont.)2026

Emergency Surgery Independently Predicts Postoperative Recurrence in Patients with Pathologic T3N0M0 Colon Cancer: A Retrospective Single-Center Cohort Study.

Selahattin Çelik, Salih Karatlı, Esra Zeynelgil, Hatice Ayyıldız Sevim, Tülay Eren

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Article in Current oncology (Toronto, Ont.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Selahattin ÇelikDepartment of Medical Oncology, Ankara Etlik City Hospital, 06010 Ankara, Türkiye.ORCID 0000-0002-5678-2633
Salih KaratlıDepartment of Medical Oncology, Ankara Etlik City Hospital, 06010 Ankara, Türkiye.ORCID 0000-0002-4237-1606
Esra ZeynelgilDepartment of Medical Oncology, Ankara Etlik City Hospital, 06010 Ankara, Türkiye.ORCID 0000-0001-7200-9440
Hatice Ayyıldız SevimDepartment of Medical Oncology, Ankara Etlik City Hospital, 06010 Ankara, Türkiye.ORCID 0000-0002-4072-5861
Tülay ErenDepartment of Medical Oncology, Ankara Etlik City Hospital, 06010 Ankara, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesPathologic stage IIA (T3N0M0) colon cancer represents a heterogeneous subgroup of stage II disease with variable recurrence risk despite similar TNM staging. Although several clinicopathological high-risk features are incorporated into current treatment guidelines, the independent prognostic significance of emergency surgery remains incompletely understood. This study aimed to identify clinicopathological predictors of postoperative recurrence, with particular emphasis on the prognostic impact of emergency surgery. MATERIALS AND

methodsThis retrospective single-center cohort study included 118 patients with pathologic T3N0M0 colon adenocarcinoma who underwent curative-intent surgery. Demographic, clinicopathological, treatment, and follow-up data were analyzed. Univariable and multivariable logistic regression analyses were performed to identify independent predictors of recurrence. Because adjuvant chemotherapy was not randomly assigned, a sensitivity analysis including adjuvant chemotherapy was conducted to address confounding by indication. Disease-free survival (DFS) was evaluated using the Kaplan-Meier method.

resultsDuring follow-up, recurrence occurred in 15 patients (12.7%). Patients with recurrence underwent emergency surgery significantly more frequently than those without recurrence (60.0% vs. 20.4%,

conclusionsAmong patients with pathologic T3N0M0 colon cancer, the need for emergency surgery was associated with a higher risk of recurrence after adjustment for other clinicopathological factors. Emergency presentation may therefore serve as an additional marker for identifying patients at increased postoperative risk. Further prospective multicenter research is needed to confirm this association and to explore its potential value when combined with molecular biomarkers for individualized postoperative management.

Indexed as

Colonic NeoplasmsNeoplasm Recurrence, LocalAgedDisease-Free SurvivalFemaleHumansMaleMiddle AgedNeoplasm StagingPrognosisRetrospective Studiescolon cancerdisease-free survivalemergency surgerypathologic T3N0M0prognostic factorsrecurrencerisk stratificationstage II colon cancer

Identifiers

PMID42782872
PMCPMC13605473

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