ArticleCells2026
Single-Cell RNA Sequencing Reveals Immune Dysregulation and Candidate Drug Targets in Endometriosis.
Marlene Rezk-Füreder, Matin Kazemi, Ayberk Alp Gyunesh, Sharon D Bryant, Peter Oppelt, Esma Hamzic-Jahic, Diana Reisinger, Celine Kapper, David Demmel, Angelika Lackner and 2 more
Abstract read
In one paragraphArticle in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Marlene Rezk-FürederExperimental Gynaecology and Obstetrics, Department of Gynaecology, Obstetrics and Gynaecological Endocrinology, Johannes Kepler University Linz, 4040 Linz, Austria.
Matin KazemiExperimental Gynaecology and Obstetrics, Department of Gynaecology, Obstetrics and Gynaecological Endocrinology, Johannes Kepler University Linz, 4040 Linz, Austria.ORCID 0009-0006-6434-1770 Ayberk Alp GyuneshExperimental Gynaecology and Obstetrics, Department of Gynaecology, Obstetrics and Gynaecological Endocrinology, Johannes Kepler University Linz, 4040 Linz, Austria.
Sharon D BryantInte: Ligand Software-Entwicklungs und Consulting GmbH, 1070 Vienna, Austria.
Peter OppeltDepartment of Gynaecology, Obstetrics and Gynaecological Endocrinology, Johannes Kepler University Linz, Kepler University Hospital, 4040 Linz, Austria.ORCID 0000-0003-3852-5948 Esma Hamzic-JahicExperimental Gynaecology and Obstetrics, Department of Gynaecology, Obstetrics and Gynaecological Endocrinology, Johannes Kepler University Linz, 4040 Linz, Austria.
Diana ReisingerDepartment of Gynaecology, Obstetrics and Gynaecological Endocrinology, Johannes Kepler University Linz, Kepler University Hospital, 4040 Linz, Austria.ORCID 0009-0009-8185-9602 Celine KapperExperimental Gynaecology and Obstetrics, Department of Gynaecology, Obstetrics and Gynaecological Endocrinology, Johannes Kepler University Linz, 4040 Linz, Austria.
David DemmelCenter for Medical Research, Medical Faculty, Johannes Kepler University Linz, 4040 Linz, Austria.ORCID 0009-0006-8373-3198 Angelika LacknerDepartment of Dermatology and Venereology, Medical Faculty, Johannes Kepler University Linz, 4040 Linz, Austria.
Kevin LangUniversity Clinic for Cardiac-, Vascular- and Thoracic Surgery, Medical Faculty, Johannes Kepler University Linz, 4040 Linz, Austria.
Barbara ArbeithuberExperimental Gynaecology and Obstetrics, Department of Gynaecology, Obstetrics and Gynaecological Endocrinology, Johannes Kepler University Linz, 4040 Linz, Austria.ORCID 0000-0001-8367-1560 Funding
10X Genomics (United States)
6 · The paper itselfAbstract
Endometriosis is a chronic inflammatory disorder affecting 5-10% of women of reproductive age and is associated with chronic pain and infertility. While research has mainly focused on local lesions, systemic immune dysfunction is increasingly implicated in disease pathogenesis. This study employs single-cell RNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) from women with endometriosis and unaffected controls, combined with integrative analysis of publicly available datasets of menstrual blood and endometrial tissues, to uncover immune dysregulation and therapeutic targets in endometriosis. Cell-type composition and pathway alterations were assessed. Upregulated genes were evaluated using pharmacophore modeling, virtual screening, molecular docking of approved drugs, and molecular dynamics simulations to explore therapeutic potential. Immune profiling revealed increased B- and T-cell subsets and widespread inflammatory dysregulation. Notably,
Indexed as
EndometriosisSequence Analysis, RNASingle-Cell AnalysisFemaleHSP90 Heat-Shock ProteinsHumansLeukocytes, MononuclearMolecular Docking SimulationSingle-Cell Gene Expression AnalysisHSP90 Heat-Shock Proteinsdrug repurposingendometriosisHSP90AA1immune dysregulationPLCG2single-cell RNA sequencing
Identifiers
PMID42782802
PMCPMC13605760
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