ArticleCells2026
Compartmentalized and Differential Regulation of NK- and γδ T-Cell Degranulation by Trophoblast-Derived Signals During Early Pregnancy.
Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Cytotoxic lymphocytes contribute to immune regulation at the maternal-fetal interface, yet their regulating mechanisms during early pregnancy remain elusive. We investigated compartment-specific NK- and γδT-cell degranulation towards trophoblast-derived signals. Blood and decidual mononuclear cells were obtained from non-pregnant women and women in early pregnancy. Spontaneous and trophoblast-mediated degranulation of NK- and γδT-cell subsets was assessed following co-culture with Sw71 extravillous trophoblast-like cells with normal and reduced expression of HLA-G/HLA-C molecules. CD107a-positive frequency and mean fluorescence intensity were quantified by flow cytometry. Statistical analyses included paired testing, multivariate analyses, and false discovery rate correction. Decidual cytotoxic lymphocytes displayed a distinct degranulation profile compared with blood counterparts. At baseline, γδT cells exhibited higher spontaneous degranulation than NK cells. Trophoblast co-culture exerted limited effects on NK-cell degranulation; however, decidual CD56
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.