Evidence map›Paper›PMID 42782788›Full record

ArticleCells2026

Human Neuronal Modeling of DLG4-Related Synaptopathy Reveals Network Dysfunction and Partial Rescue by Omega-3 Fatty Acid Docosahexaenoic Acid (DHA).

Gerardo Medina, Lilia A Rodriguez-Alcocer, Stephen Baird, Alex E MacKenzie

Abstract read
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gerardo MedinaChildren's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada.ORCID 0000-0003-2687-7022
Lilia A Rodriguez-AlcocerChildren's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada.
Stephen BairdChildren's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada.
Alex E MacKenzieChildren's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada.

Funding

DLG4 SHINE Foundation
6 · The paper itself

Abstract

DLG4-related synaptopathy (SHINE syndrome) is a rare neurodevelopmental disorder caused by pathogenic variants in

Indexed as

Disks Large Homolog 4 ProteinDocosahexaenoic AcidsFatty Acids, Omega-3Models, BiologicalNeuronsSynapsesCyclic AMP Response Element-Binding ProteinHumansCyclic AMP Response Element-Binding ProteinDisks Large Homolog 4 ProteinDLG4 protein, humanDocosahexaenoic AcidsFatty Acids, Omega-3DLG4docosahexaenoic acid (DHA)induced pluripotent stem cells (iPSCs)neuronal network activityomega-3 fatty acidsPSD-95SHINE syndromesynaptopathy

Identifiers

PMID42782788
PMCPMC13605776

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.