Evidence map›Paper›PMID 42782762›Full record

ArticleCells2026

METTL3/IGF2BP1 Axis Orchestrates m6A-Dependent NCAM1 Preservation to Combat Age-Related Cognitive Decline.

Guohua Ji, Yujie Zhao, Xu Liu, Xiaopeng Li, Liang Lu, Fengji Liang, Yanhong Yuan, Yuying Dai, Bo Li, Yanxiang Qu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Guohua JiState Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing 100094, China.
Yujie ZhaoState Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing 100094, China.
Xu LiuDepartment of Pathology and Forensics, Dalian Medical University, Dalian 116044, China.
Xiaopeng LiState Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing 100094, China.ORCID 0009-0008-2687-1695
Liang LuState Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing 100094, China.
Fengji LiangState Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing 100094, China.
Yanhong YuanState Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing 100094, China.
Yuying DaiState Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing 100094, China.
Bo LiState Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing 100094, China.
Yanxiang QuDepartment of Pathology and Forensics, Dalian Medical University, Dalian 116044, China.
Bo SongDepartment of Pathology and Forensics, Dalian Medical University, Dalian 116044, China.
Lina QuState Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing 100094, China.ORCID 0000-0002-6374-415X

Funding

Foundation of State Key Laboratory of Space Medicine, China Astronaut Research and Training Center SMFA20A01National Key R&D Program of China 2022YFA1104302, 2022YFA1604503
6 · The paper itself

Abstract

Age-related decline in learning and memory functions poses significant challenges in an aging society, with epigenetic dysregulation emerging as a key contributor to cognitive deterioration. As the most prevalent internal RNA modification, N6-methyladenosine (m6A) dynamically orchestrates neural transcriptome plasticity through its "writers," "erasers," and "readers," yet its role in aging-associated cognitive impairment remains underexplored. This study employs an integrated epitranscriptomic approach to investigate m6A-mediated regulation in hippocampal aging processes. Through comparative m6A-mRNA epitranscriptomic microarray analysis of senescence-accelerated mouse prone 8 (SAMP8) and senescence-resistant SAMR1 hippocampi, we identified neural cell adhesion molecule 1 (NCAM1) as a key m6A-regulated effector whose decreased expression correlates with accelerated cognitive deterioration. Mechanistically, we revealed that Methyltransferase-like 3 (METTL3)-mediated m6A modification governs

Indexed as

AdenosineAgingCognitive DysfunctionMethyltransferasesRNA-Binding ProteinsAnimalsEpitranscriptomeEpitranscriptomicsHippocampusHumansMaleMiceMice, Inbred C57BLRNA, MessengerRNA MethylationSignal TransductionAdenosineMethyltransferasesMettl3 protein, mouseN-methyladenosineRNA-Binding ProteinsRNA, Messengerlearning and memorym6AMETTL3NCAM1senescence

Identifiers

PMID42782762
PMCPMC13605611

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.