ReviewCells2026
The Murine Epithelial Thymic Microenvironment Is Governed by Eph/Ephrin Signalling.
Review in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the relevance of thymic epithelial cell-thymocyte interactions for thymus function has long been emphasised, the mechanisms that govern the biology of thymic epithelial cells (TECs) are not fully understood. In other epithelial tissues, erythropoietin-producing hepatocellular carcinoma (Eph) receptors and their ligands, the Eph receptor-interacting proteins (ephrins), have been demonstrated to be important regulators of epithelial homeostasis. Accordingly, we have studied the function of Eph/ephrin signalling in the organisation, phenotypes and function of mouse thymic epithelial cells, as well as its effects on T-cell differentiation, for over 20 years. This review provides a detailed description of these results, concluding that the absence of certain EphA/B receptors or ephrins B generates specific phenotypes that affect T-cell differentiation and immunological function in different ways. This suggests that the proper histological organisation of the epithelial thymic stroma is not essential for normal T-cell maturation, or that at least some aspects of the process are preserved.
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