Evidence map›Paper›PMID 42782736›Full record

ArticleCells2026

The Development of Cellular Aging Models Based on AD-MSCs.

Natalia V Elizova, Ivan V Zhivodernikov, Vyacheslav S Vasilyev, Yaroslav D Tolkachev, Yuliya V Markina, Alexander M Markin, Tatiana V Kirichenko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Natalia V ElizovaPetrovsky National Research Centre of Surgery, 119435 Moscow, Russia.ORCID 0000-0002-9646-8091
Ivan V ZhivodernikovPetrovsky National Research Centre of Surgery, 119435 Moscow, Russia.
Vyacheslav S VasilyevInstitute of Plastic Surgery and Cosmetology, 105066 Moscow, Russia.ORCID 0000-0002-2220-9695
Yaroslav D TolkachevPetrovsky National Research Centre of Surgery, 119435 Moscow, Russia.ORCID 0009-0006-5188-1890
Yuliya V MarkinaPetrovsky National Research Centre of Surgery, 119435 Moscow, Russia.ORCID 0000-0002-3781-6340
Alexander M MarkinPetrovsky National Research Centre of Surgery, 119435 Moscow, Russia.ORCID 0000-0002-6649-7924
Tatiana V KirichenkoPetrovsky National Research Centre of Surgery, 119435 Moscow, Russia.ORCID 0000-0002-2899-9202

Funding

Russian Science Foundation #25-25-00484
6 · The paper itself

Abstract

Cellular senescence of adipose tissue-derived mesenchymal stromal cells (AD-MSCs) is associated with chronic low-grade inflammation, metabolic dysfunction, and impaired adipogenesis contributing to the development of obesity, insulin resistance, and the progression of age-associated diseases. The aim of this study was to develop a model of cellular aging based on AD-MSCs to study the senolytic efficacy of the natural fisetin preparation for the subsequent development of geroprotective therapeutic strategies. The senescent markers SA-β-gal, SASP factors, and cell cycle arrest markers p16, p21, and p53 were assessed in models of replicative and stress-induced aging of AD-MSCs. H

Indexed as

Adipose TissueCellular SenescenceMesenchymal Stem CellsModels, BiologicalFlavonolsHumansHydrogen PeroxideSenotherapeuticsfisetinFlavonolsHydrogen PeroxideSenotherapeuticsadipose tissuecellular senescencefisetinMSCsSASPsenescence-associated β-galactosidase

Identifiers

PMID42782736
PMCPMC13605440

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.