ArticleCells2026
Smooth Muscle Cell MAPK14 Promotes Vascular Calcification During Hyperlipidemic Aging.
Nestor Ishimwe, Yuchi Tu, Chunhui Wang, W Bart Bryant, Wei Zhang, Yabing Chen, Xiaochun Long
Abstract read
In one paragraphArticle in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Nestor IshimweVascular Biology Center, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0001-6379-4109 Yuchi TuVascular Biology Center, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Chunhui WangVascular Biology Center, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-2706-6643 W Bart BryantVascular Biology Center, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Wei ZhangVascular Biology Center, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Yabing ChenDepartment of Pathology & Laboratory Medicine, School of Medicine, Oregon Health & Science University, Portland, OR 97239, USA.
Xiaochun LongVascular Biology Center, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0001-9714-0023 Funding
Novel Role of MAPK14 in Regulation of VSMC Contractile PhenotypeR01HL122686 · NHLBI · AUGUSTA UNIVERSITY · PI LONG, XIAOCHUN · 2014 to 2022
$4.0MCircadian regulation of vascular agingR01HL146103 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHATHAM, JOHN C, CHEN, YABING · 2019 to 2022
$2.9MProtein Arginine Methylation in Vascular Smooth Muscle Cell Phenotypic Modulation and CalcificationR01HL167201 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Yabing Chen, Xinyang Zhao · 2023 to 2026
$2.8MVascular Smooth Muscle Protein Quality Control and Aortic Aneurysm FormationR01HL170024 · NHLBI · AUGUSTA UNIVERSITY · PI Xiaochun Long, Chen Yan · 2023 to 2026
$2.7MFunction and Regulation of TSPAN2 in Vascular DiseaseR01HL139794 · NHLBI · AUGUSTA UNIVERSITY · PI LONG, XIAOCHUN · 2019 to 2023
$2.7MNovel regulation of vascular dementiaR01AG082839 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Yabing Chen · 2023 to 2026
$2.1MAmerican Heart Association 915887American Heart Association CDA34110319American Heart Association SCEFIA1156682American Heart Association TPA1141836BLRD VA I01 BX004426BLRD VA I01 BX006321NHLBI NIH HHS R01 HL122686NHLBI NIH HHS R01 HL139794NHLBI NIH HHS R01 HL146103NHLBI NIH HHS R01 HL167201NHLBI NIH HHS R01 HL170024NIA NIH HHS R01 AG082839NIH HHS 1R01AG082839-09NIH HHS 1R01HL122686-05NIH HHS 1R01HL139794-05NIH HHS 1R01HL146103-05NIH HHS 1R01HL167201-07NIH HHS 1R01HL170024-04United States Department of Veterans Affairs BX004426United States Department of Veterans Affairs BX006321United States Department of Veterans Affairs VABX005800
6 · The paper itselfAbstract
Vascular calcification is a hallmark of vascular aging that is accelerated by hyperlipidemia and contributes to adverse cardiovascular outcomes. Although vascular smooth muscle cells (VSMCs) are key mediators of vascular calcification, the signaling pathways linking aging-associated stress to osteogenic remodeling remain incompletely understood. To define the role of MAPK14 (p38α) in vascular aging, we integrated bulk RNA sequencing of young and aged mouse aortas with published single-nucleus RNA sequencing data from VSMC-specific
Indexed as
AgingHyperlipidemiasMitogen-Activated Protein Kinase 14Muscle, Smooth, VascularMyocytes, Smooth MuscleVascular CalcificationAnimalsAortaCore Binding Factor Alpha 1 SubunitMaleMiceMice, KnockoutCore Binding Factor Alpha 1 SubunitMitogen-Activated Protein Kinase 14MAPK14RUNX2vascular agingvascular calcificationvascular smooth muscle cells
Identifiers
PMID42782728
PMCPMC13605429
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