ArticleBiomimetics (Basel, Switzerland)2026
Biomimetic Chromatography Profiling of a Neurotoxicology-Relevant Compound Panel: A Physicochemical Dataset for New Approach Methodologies.
Article in Biomimetics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
Abstract
Developmental and adult neurotoxicity are hard to assess with conventional in vitro assays, which rarely account for how a chemical actually distributes once inside the body. Biomimetic chromatography offers a practical way to fill that gap, using stationary phases that mimic phospholipid membranes and major plasma proteins to yield experimental descriptors of lipophilicity, membrane affinity, and protein binding without needing radiolabeled compounds or large sample amounts. Working within the Partnership for the Assessment of Risk from Chemicals, we profiled 67 neurotoxicology-relevant chemicals on immobilized artificial membrane, human serum albumin, and alpha-1-acid glycoprotein columns alongside lipophilicity measured at three pH values. The chromatographic lipophilicity scale matched literature log
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Registered trials
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