Evidence map›Paper›PMID 42782549›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2026

Treatment burden, healthcare experiences, and health-related quality of life among youth with chronic kidney disease treated for hypertension.

Morgan Botdorf, Nicole Marchesani, Rebecca Ruebner, Elana Di Cocco, Amy J Goodwin Davies, India Shepherd Hammond, Jordan Musante, Aneta Jovanovska, Mark Levondosky, Rebecca Levondosky and 15 more

Abstract read
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Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Morgan BotdorfApplied Clinical Research Center, Departments of Pediatrics and Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. botdorfm@chop.edu.ORCID https://orcid.org/0000-0003-4884-7844
Nicole MarchesaniApplied Clinical Research Center, Departments of Pediatrics and Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Rebecca RuebnerDivision of Pediatric Nephrology, Johns Hopkins University, Baltimore, MD, USA.
Elana Di CoccoApplied Clinical Research Center, Departments of Pediatrics and Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Amy J Goodwin DaviesApplied Clinical Research Center, Departments of Pediatrics and Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
India Shepherd HammondApplied Clinical Research Center, Departments of Pediatrics and Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Jordan MusanteApplied Clinical Research Center, Departments of Pediatrics and Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Aneta JovanovskaChildren's Hospital of Philadelphia, Philadelphia, PA, USA.
Mark LevondoskyChildren's Hospital of Philadelphia, Philadelphia, PA, USA.
Rebecca LevondoskyChildren's Hospital of Philadelphia, Philadelphia, PA, USA.
Victoria H BesserDivision of Pediatric Nephrology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
Donna J ClaesDivision of Nephrology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Anne E DawsonDepartment of Pediatric Psychology and Neuropsychology, Nationwide Children's Hospital, Columbus, OH, USA.
Bradley P DixonRenal Section, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.
Caroline GluckDivision of Nephrology, Department of Pediatrics, Nemours Children's Health, Wilmington, DE, USA.
Susan M HalbachDepartment of Pediatrics, Division of Nephrology, University of Washington School of Medicine, Seattle Children's Hospital, Seattle, WA, USA.
Lyndsay HarshmanDivision of Nephrology, Dialysis & Transplantation, Stead Family Department of Pediatrics, University of Iowa Stead Family Children's Hospital, Iowa City, IA, USA.
Chryso KatsoufisDivision of Pediatric Nephrology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA.
Alexander J KulaDivision of Nephrology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Young-Hyun MoonDivision of Nephrology and Hypertension, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Larry PattersonDivision of Nephrology, Shands Children's Hospital, University of Florida, Gainesville, FL, USA.
Eloise SalmonDivision of Pediatric Nephrology, Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
Elizabeth M TalleyDivision of Nephrology, Department of Pediatrics and Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Michelle R DenburgDivision of Nephrology, Department of Pediatrics, Perelman School of Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.
Christopher B ForrestApplied Clinical Research Center, Departments of Pediatrics and Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Funding

Patient-Centered Outcomes Research Institute RD-2020C2-20338
6 · The paper itself

Abstract

backgroundControlling blood pressure (BP) is essential for slowing chronic kidney disease (CKD) progression. This study examined the associations between treatment burden, assessed by antihypertensive medication use, and health-related quality of life (HRQoL) in youth with CKD and hypertension.

methodsYouth (aged 8 to 21 years) were identified through electronic health records from 15 institutions. Youth and caregivers completed an online questionnaire assessing healthcare experiences, medication use, physical symptoms, and BP monitoring. HRQoL and related well-being domains (fatigue, anxiety, sleep disturbance, global health, and life satisfaction) were assessed using PROMIS

resultsThe study included 395 youth (M DISCUSSION: Youth with CKD and hypertension reported generally positive healthcare experiences, and antihypertensive medication use, one component of treatment burden, showed minimal association with HRQoL. Despite modest effects, continued attention to HRQoL remains an important aspect of care for youth with CKD and hypertension.

Indexed as

Antihypertensive AgentsCost of IllnessHypertensionQuality of LifeRenal Insufficiency, ChronicAdolescentCaregiversChildFemaleHumansMaleSurveys and QuestionnairesYoung AdultAntihypertensive AgentsAmbulatory blood pressure monitoringChronic kidney diseaseHypertensionPatient reported outcomesPediatricsQuality of life

Identifiers

PMID42782549

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.