Evidence map›Paper›PMID 42782479›Full record

ArticleMolecular and cellular biochemistry2026

Phytoestrogens and related microbial metabolites remodel aberrant prostate transcriptomic profiles generated upon exposure to oxidative stress.

Jiaxi Zhang, Arian Abolhassani, Cayla Boycott, Marco Tello-Palencia, Katarzyna Papierska, Ali Khan, Maidinai Sabier, David D Kitts, Barbara Stefanska

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiaxi Zhang *Human Nutrition Group, Food, Nutrition and Health Program, Faculty of Land and Food Systems, The University of British Columbia, 2205 East Mall, FNH 150, Vancouver, BC, V6T 1Z4, Canada.
Arian Abolhassani *Human Nutrition Group, Food, Nutrition and Health Program, Faculty of Land and Food Systems, The University of British Columbia, 2205 East Mall, FNH 150, Vancouver, BC, V6T 1Z4, Canada.
Cayla BoycottHuman Nutrition Group, Food, Nutrition and Health Program, Faculty of Land and Food Systems, The University of British Columbia, 2205 East Mall, FNH 150, Vancouver, BC, V6T 1Z4, Canada.
Marco Tello-PalenciaHuman Nutrition Group, Food, Nutrition and Health Program, Faculty of Land and Food Systems, The University of British Columbia, 2205 East Mall, FNH 150, Vancouver, BC, V6T 1Z4, Canada.
Katarzyna PapierskaHuman Nutrition Group, Food, Nutrition and Health Program, Faculty of Land and Food Systems, The University of British Columbia, 2205 East Mall, FNH 150, Vancouver, BC, V6T 1Z4, Canada.
Ali KhanHuman Nutrition Group, Food, Nutrition and Health Program, Faculty of Land and Food Systems, The University of British Columbia, 2205 East Mall, FNH 150, Vancouver, BC, V6T 1Z4, Canada.
Maidinai SabierFood Science Group, Food, Nutrition and Health Program, Faculty of Land and Food Systems, The University of British Columbia, Vancouver, BC, Canada.
David D KittsFood Science Group, Food, Nutrition and Health Program, Faculty of Land and Food Systems, The University of British Columbia, Vancouver, BC, Canada.
Barbara StefanskaHuman Nutrition Group, Food, Nutrition and Health Program, Faculty of Land and Food Systems, The University of British Columbia, 2205 East Mall, FNH 150, Vancouver, BC, V6T 1Z4, Canada. barbara.stefanska@ubc.ca.

Funding

Canada Foundation for Innovation 37105Natural Sciences and Engineering Research Council of Canada RGPIN-2019-04885Natural Sciences and Engineering Research Council of Canada RGPIN-2021-02969
6 · The paper itself

Abstract

Dietary phytoestrogens, including pterostilbene (PTS) from berries and genistein (GEN) from soybeans, exert anti-oxidant and anti-inflammatory effects in prostate cancer. However, the specific actions in regulation of cell biology and homeostasis in normal prostate epithelial cells remain unknown and a prominent research gap refers to the effects of related microbial metabolites of phytoestrogens. We therefore explored effects of distinct phytoestrogens, PTS and GEN, and PTS microbial metabolite, pinostilbene (PNS), in healthy cells with disrupted homeostasis. Human RWPE-1 prostate epithelial cells were treated with 100 µM concentration of hydrogen peroxide (H

Indexed as

Microbial metabolitesPhytoestrogensProstate epithelial cellsTranscriptomics

Identifiers

PMID42782479

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.