ReviewAdvances in experimental medicine and biology2026
Autonomous Oscillations of NF-κB.
Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
The nuclear factor κB (NF-κB) signaling pathway plays a crucial role in regulating immune responses, inflammation, and cell survival. After the discovery of NF-κB by Ranjan Sen and David Baltimore as a nuclear factor that binds near the κ light-chain gene in activated B-cells [1], extensive research has been conducted to uncover key biochemical mechanisms underlying the pathway and the downstream genes regulated by NF-κB. The core regulatory module of NF-κB/IκB (inhibitor of NF-κB)/IKK (IκB kinase) has also been a leading example of cell signaling pathways that can produce oscillatory activities, particularly in response to the pro-inflammatory cytokine tumor necrosis factor α (TNF-α). Despite this status, the existence and function of NF-κB oscillations was a contentious topic in the early years. In this chapter, we touch on the history, progression, and outlook of the quest to decipher the properties and biological function of NF-κB oscillations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.