ReviewAdvances in experimental medicine and biology2026
Repurposing Cell Cycle Oscillators for Multiciliated Cell Differentiation.
Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Repurposing extant resources is at the basis of functional innovation in evolution. In cell biology, conserved regulatory circuits, with minor adjustments to a subset of components, can be recruited for functional novelty. A prominent example concerns multiciliated cells that generate cilia-based fluid flows, vital for organism development and homeostasis. During their post-mitotic differentiation, these cells repurpose the autonomous oscillators that normally govern the cell division cycle to drive massive production of cilia-nucleating organelles, named centrioles, in the cytoplasm without committing to cell division. In this chapter, we review recent advances in understanding how a repurposed cell cycle machinery regulates these cytoplasmic dynamics essential for motile ciliogenesis.
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