SynthesisCell and tissue banking2026
Utilization of human amniotic membrane (HAM) in tympanoplasty: a systematic review and meta-analysis.
Synthesis in Cell and tissue banking, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
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Abstract
Tympanic membrane perforation is a common otologic disorder. In cases where spontaneous closure does not occur, or when the perforation is associated with clinically significant symptoms that adversely affect quality of life, surgical repair is often indicated. This review and meta-analysis aimed to synthesize and critically appraise the current evidence on the use of human amniotic membrane (HAM) as a graft material in tympanoplasty. A systematic literature search was conducted in multiple databases for studies published up to November 2025. The following search terms were used in titles and abstracts (with corresponding MeSH terms applied in PubMed): "Amnion" OR "Placenta" AND "Tympanoplasty." Single-arm meta-analysis using a random effects model was performed to assess improvement in the air-bone gap (ABG) and anatomical closure rates. Standardized methodological criteria were applied to assess study quality and risk of bias. Out of 630 identified records, eight studies evaluating 265 tympanoplasties (264 patients) using amniotic membrane grafting (AMG) were included. The majority of non-randomized studies carried a serious risk of bias. A single-arm meta-analysis of 4 studies demonstrated a pooled complete anatomical closure rate of 92% (95% CI 0.79-0.98; I
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.