Evidence map›Paper›PMID 42782378›Full record

ArticleJournal of molecular histology2026

Protective and therapeutic roles of Phoenix dactylifera L. Zaghloul cultivar leaves extract against ethanol-induced gastric ulcer in rats.

Hanan F Aly, Mohamed I Mabrouk, Mohamed B Shalaby, Karima A Hamed, Wagdy K B Khalil, Salma El Sawi, Amal M El-Feky, Marwa M Elbatanony, Mohamed S Salim, Hanan S Kiwan

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Article in Journal of molecular histology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hanan F AlyTherapeutic Chemistry, Department, National Research Centre, 33El Buhouth St., Dokki, Cairo, 12622, Egypt. hanan_abduallah@yahoo.com.ORCID https://orcid.org/0000-0003-3642-1571
Mohamed I MabroukDepartment of Physical Therapy, Faculty of Allied Medical Sciences, Applied Science Private University, Amman, Jordan.
Mohamed B ShalabyToxicology Research Department, Research Institute of Medical Entomology, General Organization of Teaching Hospitals and Institutes, MOHP, Cairo, Egypt.
Karima A HamedDepartment of Cell Biology, Biotechnology Research Institute, National Research Centre, 33 El-Bohouth St., Cairo, 12622, Egypt.
Wagdy K B KhalilDepartment of Cell Biology, Biotechnology Research Institute, National Research Centre, 33 El-Bohouth St., Cairo, 12622, Egypt.
Salma El SawiPharmacognosy Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, P.O. 12622, 33El Buhouth St., Dokki, Cairo, Egypt.
Amal M El-FekyPharmacognosy Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, P.O. 12622, 33El Buhouth St., Dokki, Cairo, Egypt.
Marwa M ElbatanonyPharmacognosy Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, P.O. 12622, 33El Buhouth St., Dokki, Cairo, Egypt.
Mohamed S SalimMedical Laboratory Technology Department, Higher Technological Institute of Applied Health Sciences, Beni-Suef, Egypt.
Hanan S KiwanMedical Physiology Department, Medical Research and Clinical Studies Institute, National Research Centre, P.O. 12622, 33El-Bohouth St., Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric ulcer is a common gastrointestinal disorder associated with oxidative stress, inflammation, and disruption of the gastric mucosal barrier. This study investigated the gastroprotective and therapeutic effects of Phoenix dactylifera (Zaghloul) methanolic leaves extract against ethanol-induced gastric ulcer in male Wistar rats. Phenolic quantification of the extract revealed the presence of phenolic (2450.127 mg GAE/g) and flavonoid (2230.00 mg CE/g) contents. LC-ESI-MS-MS analysis led to detection of 23 compounds. Ethanol administration resulted in elevation of MDA, inflammatory modulators (TNF-α, ICAM-1 and IL-10) and reduction of TAC, GSH and cycloxygenase enzymes (COXI and COXII). Expression of E2F1, RAD21, NIBPL, and Vimentin genes was increased via ulcer induction. Treatment with the extract reversed ethanol effects by elevating TAC, GSH, COXI and COXII and reducing MDA, TNF-α, ICAM-1 and IL-10;TNF-α/IL-10 ratio was increased in the ulcerative group and reduced by treatment. Moreover, the extract modulated the expression of E2F1, RAD21, NIBPL, and Vimentin suggesting a potential association with attenuation of epithelial injury and mucosal repair. Histopathological examination demonstrated improvement of the mucosal architecture and mucin production, and reduction of fibrosis. Collectively, these findings demonstrate the impact of ulcer induction and extract treatment on the expression of the studied genes and support the gastroprotective and therapeutic effects of P. dactylifera leaves extract through antioxidant, anti-inflammatory, and mucosal healing activities. Further studies at the protein level using more dosages of the extract are needed to clarify the mechanistic significance of these gene expression changes and the appropriate dose of the extract.

Indexed as

PhoeniceaePlant ExtractsPlant LeavesStomach UlcerAnimalsEthanolMaleOxidative StressRatsRats, WistarEthanolPlant ExtractsAnti-inflammatoryAntioxidantE2F1FlavonoidsGastric ulcerGastroprotectiveIL-10NIBPL and VimentinPhenolicsPhoenix dactyliferaRAD21TNF-α

Identifiers

PMID42782378

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.