ArticleEuropean journal of applied physiology2026
Resting pulsatile cerebrovascular hemodynamics in people with Down syndrome.
Article in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Individuals with Down syndrome (DS) exhibit reduced resting cerebral blood flow (CBF) and altered arterial pulsatility. Pulsatility and its transmission from extracranial [internal carotid (ICA), vertebral (VA)] to intracranial [middle (MCA), posterior (PCA)] arteries is characterized utilizing the damping factor index (DFi), with values > 1 suggesting attenuation of pulsatility, and < 1 indicating harmful transmission. To our knowledge, resting cerebral arterial pulsatility in individuals with DS has not been assessed. Therefore, the present study investigated resting attenuation of arterial pulsatility, quantified using the DFi, and CBF in individuals with DS (DS; n = 16, 5 females) and age- and sex-matched controls (n = 16, 5 females). Participants were instrumented in a semi-recumbent position for 10 minutes. During this period, heart rate, blood pressure, end-tidal oxygen and carbon dioxide, and MCA and PCA velocities were continuously measured. Following this, one-minute ICA and VA blood flow measures were performed via vascular duplex ultrasound. Anterior DFi was not different between individuals with DS (1.76 ± 0.55 a.u.) vs. controls (1.93 ± 0.66 a.u.; p = 0.453). Posterior DFi was greater in DS (3.17 ± 0.70 a.u.) vs. controls (2.30 ± 0.59 a.u.; p = 0.001). These data suggest that individuals with DS can attenuate arterial pulsatility under resting conditions.
Indexed as
Identifiers
42782333What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.