Evidence map›Paper›PMID 42782160›Full record

ArticleChild: care, health and development2026

Are School-Aged Children Who Self-Identify as Neurodivergent at Greater Risk of Substance Misuse? A Study of 20 000 Secondary School Students.

John Headley Ward, Francesca Happé, Mina Fazel

Abstract read
In one paragraph

Article in Child: care, health and development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

John Headley WardDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-9108-7900
Francesca HappéSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID https://orcid.org/0000-0001-9226-4000
Mina FazelDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0001-9342-2365

Funding

National Institute for Health and Care ResearchNational Institute for Health and Care Research (NIHR) Maudsley Biomedical Research CentreNIHR Academic Clinical FellowshipNIHR Applied Research Collaboration Oxford and Thames ValleyWestminster Foundation
6 · The paper itself

Abstract

backgroundNeurodiversity is becoming a more widely used term amongst the general population, recognising neurodivergent people outside of traditional deficit-based models of neurodevelopmental conditions such as autism, ADHD, dyslexia and dyspraxia. Although neurodevelopmental conditions have been associated with a variety of externalising behaviours, including substance misuse, there is limited research looking at whether the broader neurodivergent population may also share these risks. This study's primary aim was to understand the relationship between self-reported neurodivergence and different forms of substance misuse in adolescents.

methodsThis study uses data from the 2023 wave of the OxWell Student Survey, analysing responses from 21 749 secondary school-aged children in England. Firth logistic regression was used to analyse the relationship between self-reported neurodivergence and frequent use of substances (vapes, cigarettes, alcohol and recreational drugs). Models were adjusted for demographic variables (gender, age, ethnicity, socioeconomic status and family history of substance use) and psychological variables (well-being scores, anxiety/depression measures).

results25.1% of our sample identified as neurodivergent. Our analyses demonstrate that although levels of frequent substance misuse are generally low amongst school-aged children (< 10%), neurodivergent children were significantly more likely to be in higher substance use categories (daily vaping/smoking, frequent drinking, binge drinking and lifetime illicit substance use).

conclusionsOur findings provide preliminary evidence that children who identify as neurodivergent are at greater risk of substance misuse, even after adjusting for other known risk factors. Furthermore, this study supports the need for scalable school-based substance use preventive interventions that are applicable for neurodivergent young people.

Indexed as

Substance-Related DisordersAdolescentChildEnglandFemaleHumansMaleRisk FactorsSelf ReportStudentsADHDadolescentsautismneurodiversitysubstance use

Identifiers

PMID42782160
PMCPMC13603042

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.