Evidence map›Paper›PMID 42782046›Full record

ArticleJACC. Case reports2026

Systemic Oxalosis Mimicking Transthyretin Amyloid Cardiomyopathy: A Cause of False Positive Tc-99m PYP Scintigraphy.

Bhavya Ancha, Virginia Hahn, Charles Steenbergen, Cheng-Ying Ho, Ahmad Kohsar, Emily Brown, Mark Ranek, Claire Brookmeyer, Michael Polydefkis, Joban Vaishnav

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bhavya AnchaDepartment of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Virginia HahnDepartment of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Charles SteenbergenDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Cheng-Ying HoDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Ahmad KohsarDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Emily BrownDepartment of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Mark RanekDepartment of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Claire BrookmeyerDepartment of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.
Michael PolydefkisDepartment of Neurology, Johns Hopkins University, Baltimore, Maryland, USA.
Joban VaishnavDepartment of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA. Electronic address: jvaishn1@jhmi.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTechnetium-99m pyrophosphate (Tc-99m PYP) scintigraphy is a noninvasive imaging modality in the diagnosis of transthyretin amyloid cardiomyopathy (ATTR-CM), though false positive results may result in adverse clinical outcomes. CASE SUMMARY: A 53-year-old man with a history of heart failure with reduced ejection fraction and end-stage renal disease presented with upper extremity weakness and hypervolemia. Tc-99m PYP scintigraphy was suggestive of ATTR-CM. However, transthyretin genetic testing was negative, and endomyocardial biopsy was without evidence of amyloid deposition. The patient later died, and autopsy revealed myocardial oxalate deposition concerning for primary vs secondary hyperoxaluria. DISCUSSION: Although Tc-99m PYP scintigraphy is a sensitive and specific modality for the detection of ATTR-CM, clinicians should recognize other infiltrative cardiomyopathies causing false positivity such as systemic oxalosis.

Indexed as

cardiomyopathydiastolic heart failurenuclear medicine

Identifiers

PMID42782046
PMCPMC13616548

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.